Cure possible for CML?                 Chronic myeloid leukemia

"There are a number of approaches for selective targeting of leukemic stem cells
(LSCs). These include targeting stem-cell properties, such as self-renewal,
inducing cycling of quiescent LSCs to sensitize them to conventional agents,
employing or inducing immune-based mechanisms, and targeting tumor-specific
physiology. Agents such as parthenolide inhibit the ability of leukemic stem
cells to respond to oxidative stress and make leukemic stem cells and bulk
leukemic cells susceptible to cell death, while normal stem cells remain
relatively unharmed by these agents. The major mechanism of action of these
small molecules appears to revolve around the aberrant glutathione metabolism
pathway found in leukemic cells." 
Extract of How close are we to targeting the leukemia stem cell? 
                          by Best  Practice & Research Clinical Haematology

ARTICLES
Researchers in Singapore find common therapeutic vulnerability for a genetically diverse and deadly leukaemia
March 17, 2020, DUKE NUS Medical School

A randomised phase II trial of hydroxychloroquine and imatinib versus imatinib alone for patients with chronic myeloid leukaemia in major cytogenetic response with residual disease
January 10, 2020, PubMed

Inhibition of KPNB1 Inhibits Proliferation and Promotes Apoptosis of Chronic Myeloid Leukemia Cells Through Regulation of E2F1
December 2, 2019, Dovepress

Druggable Biochemical Pathways and Potential Therapeutic Alternatives to Target Leukemic Stem Cells and Eliminate the Residual Disease in Chronic Myeloid Leukemia
November 10, 2019, Inserm

Antibody eradicates leukemia stem cells
October 15, 2019, UCLA

Chronic myelogenous leukemia stem cells require cell-autonomous pleiotrophin signaling
October 15, 2019, JCI

Targeting BCR-ABL1 in Chronic Myeloid Leukemia by PROTAC-Mediated Targeted Protein Degradation
September 15, 2019, PubMed

Iron and leukemia: new insights for future treatments
September 13, 2019, Journal of Experimental & Clinical Cancer Research

Combined inhibition of MDM2 and Bcr-Abl tyrosine kinase targets chronic myeloid leukemia stem/progenitor cells in a murine model
August 2019, Haematologica

Infliximab therapy together with tyrosine kinase inhibition targets leukemic stem cells in chronic myeloid leukemia
July 4, 2019, PubMed

CML hematopoietic stem cells expressing IL-1RAP can be targeted by chimeric antigen receptor (CAR)-engineered T cells
December 4, 2018, American Association for Cancer Research

​​Possible Achilles' Heel of Leukemia Stem Cells
November 16, 2018, Technology Networks

New Combo for Chronic Myeloid Leukemia Shows Activity In Vitro
October 16, 2018, Cancer Therapy Advisor

City of Hope Study Published in Nature Medicine Reports on Promising New Drug to Fight Chronic Myelogenous Leukemia
March 5, 2018, BusinessWire

Bone marrow niche trafficking of miR-126 controls the self-renewal of leukemia stem cells in chronic myelogenous leukemia
March 5, 2018, Nature Medicine

C1206, a novel curcumin derivative, potently inhibits Hsp90 and human chronic myeloid leukemia cells in vitro
December 7, 2017, Nature

Immature CML cells implement a BMP autocrine loop to escape TKI treatment
November 14, 2017, Journal Blood

Altered intracellular signaling by imatinib increases the anti‐cancer effects of tyrosine kinase inhibitors in chronic myelogenous leukemia cells
December 7, 2017, NCBI
​
Antibiotic could help treat CML
September 22, 2017, Hematology Times

Cobll1 is linked to drug resistance and blastic transformation in chronic myeloid leukemia
February 24, 2017, Leukemia

Induction of p53 suppresses chronic myeloid leukemia
January 13, 2017, PublMed

Enhanced targeting of CML stem and progenitor cells by inhibition of porcupine acyltransferase in combination with TKI.
December 23, 2016, PublMed

Ezh2 Inhibitors May Offer Cure for Chronic Myelogenous Leukemia
September 21, 2016 , Oncology Nurse Advisor
 
EZH2 May Be Required for CML Initiation, Could Represent Therapeutic Target
September 19, 2016 , Cancer Network

Prospect of shorter treatment and cure for chronic myelogenous leukemia
September 14, 2016, Havard Gazette

Discovery offers prospect of shorter treatment and cure for chronic myelogenous leukemia
September 14, 2016, Dana-Farber Cancer Institute

Combined targeting of BCL-2 and BCR-ABL tyrosine kinase eradicates chronic myeloid leukemia stem cells
September 7, 2016,  Science translational Medicine

Cancer Breakthrough: Scientists find drugs to target ‘Achilles heel’ of leukaemia
Jun 8, 2016, Express

Scientists identify drugs to target ‘Achilles heel’ of Chronic Myeloid Leukaemia cells
June 8, 2016, The University of Manchester

93 percent of advanced leukemia patients in remission after immunotherapy
April 27, 2016, ScienceDaily

Excitement at new cancer treatment
February 16,2016, BBC.com

Novel oral transforming growth factor-β signaling inhibitor EW-7197 eradicates CML-initiating cells
January 26, 2016, Cancer Science

Breakthrough on leukaemia
January 2, 2016, MailOnline

Anti-Leukemic Effects of Venetoclax on Philadelphia Chromosome Positive Leukemia Cells
2016, Journal Blood

Antileukemic Effect of Tualang Honey on Acute and Chronic Leukemia Cell Lines
2015, Hindawi

Inecalcitol, a Novel Adjuvant Therapy Inhibiting Chronic Myeloid Leukemia (CML) Stem Cells,  Activates a Macrophage Differentiation Pathway in Leukemic Progenitors
December 7, 2015, ASH 2015

Discovery of an Embryonic Switch for Cancer Stem Cell Generation
November 30, 2015, UC San Diego Health

A hostel for the hostile: the bone marrow niche in hematologic neoplasms
November 2015, Haematologica

Targeting Human Cancer by a Glycosaminoglycan Binding Malaria Protein
October 15, 2015, Cancer cell
 
Malaria vaccine provides hope for a general cure for cancer
October 13, 2015,  University of Copenhagen

Adding Glitazone to Chemotherapy May Help Treat Chronic Myeloid Leukemia
September 3, 2015, Cancer Therapy Advisor

Starving Cancer Stem Cells To Stop Cancer
September 2, 2015, Asian Scientist

How do harmful chronic myelogenous leukemia stem cells obtain their nutrients?
August 27, 2015, EurekAlert

Is this a miracle cancer vaccine? Scientists hail breakthrough treatment as a 'game changer'
March 21, 2015, MailOnline

Effects of quercetin on hedgehog signaling in chronic myeloid leukemia KBM7 cells
October 24, 2014, PublMed

The BCL2 inhibitor ABT-199 significantly enhances imatinib-induced cell death in chronic myeloid leukemia progenitors.
October 15, 2014, PublMed

SL-401 and SL-501, targeted therapeutics directed at the interleukin-3 receptor, inhibit the growth of leukaemic cells and stem cells in advanced phase chronic myeloid leukaemia
June 19, 2014, British Journal of Haematology

JAK2/STAT5 inhibition by nilotinib with ruxolitinib contributes to the elimination of chronic phase CML CD34+ cells in vitro and in vivo
June 16, 2014, Journal Blood

New discovery could soon make leukemia history
June 11, 2014, Business Standard

Breakthrough in cancer research as treatment is developed that gets cancer cells to kill themselves: 'Paradigm-shifting' discovery will DRAMATICALLY reduce side effects and need for ongoing therapy
June 10, 2014,  Mail Online

Game Changer for Leukemia Therapy
June 10, 2014, Newswise

Differential regulation of myeloid leukemias by the bone marrow microenvironment.
November 19, 2103, PubLmed

Bone Drug Kills  Leukemia in Mice
November 1, 2013, Bioscience  Technology

Evicting Leukemia - Bone drug kills resistant cancer stem cells by making home unlivable
October 31, 2013, Harvard medical school

Ottawa researchers hopeful nano-particles can cure leukemia    
August 13, 2013, CTV News

Perspective: Combined forces
June 27, 2013, Nature

Cell-Based Immune Therapy Shows Promise  in Leukemia Patients
March 20, 2013,  Memorial Sloan-Kettering Cancer  Center

Sabutoclax (ONT-701) May BeThe Next Magic Bullet To Combat The Root Of Cancer
January 30 2013,  Science  2.0
 
Pan–BCL-2 Inhibition Sensitizes Leukemic Stem Cells to Kinase  Inhibitors
January 24, 2013, Cancer  Discovery

Sabutoclax appears to selectively target leukemia stem cells that  are responsible for relapses
January 18, 2013, News  Medical

A new enzyme that contributes to  the proliferation of leukemia is discovered
December 26, 2012, Private MD News

How close are we to targeting the leukemia stem cell?
December 2012,  Best Practice & Research Clinical Haematology

DNA-repair problems destroy hardy leukemia cells
December 26, 2012,  OncologyNurseAdvisor 

Reprogramming enzyme promotes chronic myeloid  leukemia
Decenber 25, 2012,  Omglobe.com

Enzyme accelerates malignant stem cell cloning in chronic myeloid  leukemia
December 24, 2012, Eurekalert
 
Latest Treatment and Research for Chronic Myeloid  Leukemia
December 24, 2012, Cancer  Network

Sabutoclax, a Novel Pan BCL2 Family Inhibitor, Sensitizes Dormant Blast Crisis Chronic Myeloid Leukemia Stem Cells to Dasatinib
December 10, 2012, ASH  2012

RAD52-Dependent Synthetic Lethality Eradicates Leukemia Stem  Cells
December 9, 2012, ASH  2012

Temple scientists target DNA repair to eradicate leukemia stem cells
December 9, 2012, MedicalXpress

New breakthrough gives hope to cancer sufferers
July 10, 2012, ABC News

New blood cancer treatment to be tested
July 10, 2012, AdelaideNow

Drug may avert chemo side  effects
July 10, 2012,   The Age  National

New Target Discovered Deep Within Cancer Cells
July 9, 2012, Science Daily

Methods for Detection and Elimination of Dormant Cancer Stem Cells
June 19, 2012, Ibridge

Biomarker to Enable Eradication of CML Stem Cells
June 14, 2012, Ibridge

Identification of Drugs Including a Dopamine Receptor Antagonist that Selectively Target Cancer Stem Cells
May 24, 2012, Cell

Looking for tools to shut down leukemia for good
May 1, 2012, City of Hope

Altered Microenvironmental Regulation of Leukemic and Normal Stem Cells in Chronic Myelogenous Leukemia
April 17, 2012, Cancer Cell

To Prevent Leukemia's Dreaded Return, Go for the Stem Cells
April 5, 2012, Science Daily
Chronic Myeloid Leukemia: Are We Close to Finding a Cure?
February 23, 2012, American Health & Drug Benefits

Therapy targets leukemia stem cells
February 13, 2012, Eurekalert

HIF1α is required for survival maintenance of chronic myeloid leukemia stem cells
January 24, 2012, Journal Blood

Phase 1 Clinical Trial of KB004 in  EphA3-Expressing Hematologic  Malignancies
January 2012, Monash  University

Possible cure for CML in Fish Oil
December 22, 2011, CMLeukemia

Minimal Residual Disease and Discontinuation of Therapy in Chronic Myeloid Leukemia: Can We Aim at a Cure?
December 10, 2011, Hematology

Canadian researchers find potential new leukemia treatment with old antibiotic drug
November 20. 2011, Canadian Biotechnologist 2.0

The End of Cancer. DCA makes its world debut.
May 22, 2011, Arbitrage Magasine

CML biology for the clinician in 2011: six impossible things to believe before breakfast on the way to cure
2011, Vol18, No 4, Current Oncology

New approach to leukemia chemotherapy -- is a cure in sight?
March 30, 2011, ScienceDaily

Hematology: Curing CML with imatinib—a dream come true?
February 1, 2011, Nature Reviews Clinical Oncology

Safety of Zileuton (Zyflo) in Combination With Imatinib Mesylate (Gleevec) in CML
September 2010, ClincalTrials.gov

Target of Rapamycin Signaling in Leukemia and Lymphoma
September 8, 2010, Clinical cancer Research

Isolation and killing of candidate chronic myeloid leukemia stem cells by antibody targeting of IL-1 receptor accessory protein
August 30, 2010, PubMed  Central

Combination Therapy Targets Stubborn Leukemia Stem Cells
May 17,2010, Science Daily

Vaccine may cure chronic myeloid leukemia CML
January 10, 2010, Health Newstrack

Irish scientists ‘close to finding leukaemia cure’
November 24, 2009, Belfast Telegraph

Irish leukaemia drug trials 'promising'
November 23, 2009, RTÉ News

Adelaide researchers on road to myeloid leukemia cure
October 2009, NEWS.COM.AU

The leukemic stem cell
2008, NCBI

Surviving  CML pre-imatinib era

               In 1981, Dr. Robert Patenaude from Quebec  (Canada) was diagnosed with CML. He has gone through a bone marrow transplant in 1982, when he was a second-year medical student. He wrote a book Surviving Leukemia: A Practical Guide (Your Personal Health) . After 29 years, he didn’t  relapse.  If you understand French, you can see some videos featuring Dr Robert Patenaude

                                 See also Treatment free remission (TFR)