Cure possible for CML? Chronic myeloid leukemia
"There are a number of approaches for selective targeting of leukemic stem cells
(LSCs). These include targeting stem-cell properties, such as self-renewal,
inducing cycling of quiescent LSCs to sensitize them to conventional agents,
employing or inducing immune-based mechanisms, and targeting tumor-specific
physiology. Agents such as parthenolide inhibit the ability of leukemic stem
cells to respond to oxidative stress and make leukemic stem cells and bulk
leukemic cells susceptible to cell death, while normal stem cells remain
relatively unharmed by these agents. The major mechanism of action of these
small molecules appears to revolve around the aberrant glutathione metabolism
pathway found in leukemic cells."
Extract of How close are we to targeting the leukemia stem cell?
by Best Practice & Research Clinical Haematology
(LSCs). These include targeting stem-cell properties, such as self-renewal,
inducing cycling of quiescent LSCs to sensitize them to conventional agents,
employing or inducing immune-based mechanisms, and targeting tumor-specific
physiology. Agents such as parthenolide inhibit the ability of leukemic stem
cells to respond to oxidative stress and make leukemic stem cells and bulk
leukemic cells susceptible to cell death, while normal stem cells remain
relatively unharmed by these agents. The major mechanism of action of these
small molecules appears to revolve around the aberrant glutathione metabolism
pathway found in leukemic cells."
Extract of How close are we to targeting the leukemia stem cell?
by Best Practice & Research Clinical Haematology
Various topics about possibility of cure
Inhibition of STAT5 in conjunction with standard TKI therapy
Combination of pioglitazone with tyrosine kinase inhibitor
Combination of miristen with tyrosine kinase inhibitor
Combination of ruxolitinib with tyrosine kinase inhibitor
Combination of Inecalcitol with tyrosine kinase inhibitor
Combination of interferon with tyrosine kinase inhibitor
Combination of Pembrolizumab with tyrosine kinase inhibitor
Combination of Venetoclax with tyrosine kinase inhibitor
Combination of dasatinib plus Nivolumab
Ezh2 Inhibitors May Offer Cure for CML?
Inhibitory effect of c-Myc on p53-induced apoptosis in leukemia cells
The CRISPR-Cas9 gene-editing technique
Can immunotherapy cure leukemia?
CML Vaccine
Can genetic sequencing help to cure leukemia?
Can the new drug CX-5461 cure leukemia?
Math could help cure leukemia
NATURAL MEDICINE
Betel leaf may help fight CML
Can curcumin cure leukemia?
Feverfew extract (parthenolide)
Possible cure for CML in Fish Oil
Can dandelions kill cancer?
VIDEOS
City of Hope working on potential leukemia breakthrough | ABC7
March 8, 2018, ABC7Second-line
Is it possible to reach an operational cure for CML?
June 24, 2016, VJHemOnc – Video Journal of Hematological Oncology
ARTICLES
Treatment-Free Remission at Heart of New CML Study
November 14, 2019, AJMC
Druggable Biochemical Pathways and Potential Therapeutic Alternatives to Target Leukemic Stem Cells and Eliminate the Residual Disease in Chronic Myeloid Leukemia
November 10, 2019, Inserm
Antibody eradicates leukemia stem cells
October 15, 2019, UCLA
Chronic myelogenous leukemia stem cells require cell-autonomous pleiotrophin signaling
October 15, 2019, JCI
Combined inhibition of MDM2 and Bcr-Abl tyrosine kinase targets chronic myeloid leukemia stem/progenitor cells in a murine model
August 2019, Haematologica
Infliximab therapy together with tyrosine kinase inhibition targets leukemic stem cells in chronic myeloid leukemia
July 4, 2019, PubMed
CML hematopoietic stem cells expressing IL-1RAP can be targeted by chimeric antigen receptor (CAR)-engineered T cells
December 4, 2018, American Association for Cancer Research
Possible Achilles' Heel of Leukemia Stem Cells
November 16, 2018, Technology Networks
New Combo for Chronic Myeloid Leukemia Shows Activity In Vitro
October 16, 2018, Cancer Therapy Advisor
City of Hope Study Published in Nature Medicine Reports on Promising New Drug to Fight Chronic Myelogenous Leukemia
March 5, 2018, BusinessWire
Bone marrow niche trafficking of miR-126 controls the self-renewal of leukemia stem cells in chronic myelogenous leukemia
March 5, 2018, Nature Medicine
C1206, a novel curcumin derivative, potently inhibits Hsp90 and human chronic myeloid leukemia cells in vitro
December 7, 2017, Nature
Immature CML cells implement a BMP autocrine loop to escape TKI treatment
November 14, 2017, Journal Blood
Altered intracellular signaling by imatinib increases the anti‐cancer effects of tyrosine kinase inhibitors in chronic myelogenous leukemia cells
December 7, 2017, NCBI
Antibiotic could help treat CML
September 22, 2017, Hematology Times
Cobll1 is linked to drug resistance and blastic transformation in chronic myeloid leukemia
February 24, 2017, Leukemia
Induction of p53 suppresses chronic myeloid leukemia
January 13, 2017, PublMed
Enhanced targeting of CML stem and progenitor cells by inhibition of porcupine acyltransferase in combination with TKI.
December 23, 2016, PublMed
Ezh2 Inhibitors May Offer Cure for Chronic Myelogenous Leukemia
September 21, 2016 , Oncology Nurse Advisor
EZH2 May Be Required for CML Initiation, Could Represent Therapeutic Target
September 19, 2016 , Cancer Network
Prospect of shorter treatment and cure for chronic myelogenous leukemia
September 14, 2016, Havard Gazette
Discovery offers prospect of shorter treatment and cure for chronic myelogenous leukemia
September 14, 2016, Dana-Farber Cancer Institute
Combined targeting of BCL-2 and BCR-ABL tyrosine kinase eradicates chronic myeloid leukemia stem cells
September 7, 2016, Science translational Medicine
Cancer Breakthrough: Scientists find drugs to target ‘Achilles heel’ of leukaemia
Jun 8, 2016, Express
Scientists identify drugs to target ‘Achilles heel’ of Chronic Myeloid Leukaemia cells
June 8, 2016, The University of Manchester
93 percent of advanced leukemia patients in remission after immunotherapy
April 27, 2016, ScienceDaily
Excitement at new cancer treatment
February 16,2016, BBC.com
Novel oral transforming growth factor-β signaling inhibitor EW-7197 eradicates CML-initiating cells
January 26, 2016, Cancer Science
How A Canadian Researcher Is Advancing Breakthrough Therapies
January 22, 2016, Personal Health News
Breakthrough on leukaemia
January 2, 2016, MailOnline
Anti-Leukemic Effects of Venetoclax on Philadelphia Chromosome Positive Leukemia Cells
2016, Journal Blood
Antileukemic Effect of Tualang Honey on Acute and Chronic Leukemia Cell Lines
2015, Hindawi
Inecalcitol, a Novel Adjuvant Therapy Inhibiting Chronic Myeloid Leukemia (CML) Stem Cells, Activates a Macrophage Differentiation Pathway in Leukemic Progenitors
December 7, 2015, ASH 2015
Discovery of an Embryonic Switch for Cancer Stem Cell Generation
November 30, 2015, UC San Diego Health
A hostel for the hostile: the bone marrow niche in hematologic neoplasms
November 2015, Haematologica
Targeting Human Cancer by a Glycosaminoglycan Binding Malaria Protein
October 15, 2015, Cancer cell
Malaria vaccine provides hope for a general cure for cancer
October 13, 2015, University of Copenhagen
Adding Glitazone to Chemotherapy May Help Treat Chronic Myeloid Leukemia
September 3, 2015, Cancer Therapy Advisor
Starving Cancer Stem Cells To Stop Cancer
September 2, 2015, Asian Scientist
How do harmful chronic myelogenous leukemia stem cells obtain their nutrients?
August 27, 2015, EurekAlert
Is this a miracle cancer vaccine? Scientists hail breakthrough treatment as a 'game changer'
March 21, 2015, MailOnline
Effects of quercetin on hedgehog signaling in chronic myeloid leukemia KBM7 cells
October 24, 2014, PublMed
The BCL2 inhibitor ABT-199 significantly enhances imatinib-induced cell death in chronic myeloid leukemia progenitors.
October 15, 2014, PublMed
SL-401 and SL-501, targeted therapeutics directed at the interleukin-3 receptor, inhibit the growth of leukaemic cells and stem cells in advanced phase chronic myeloid leukaemia
June 19, 2014, British Journal of Haematology
JAK2/STAT5 inhibition by nilotinib with ruxolitinib contributes to the elimination of chronic phase CML CD34+ cells in vitro and in vivo
June 16, 2014, Journal Blood
New discovery could soon make leukemia history
June 11, 2014, Business Standard
Breakthrough in cancer research as treatment is developed that gets cancer cells to kill themselves: 'Paradigm-shifting' discovery will DRAMATICALLY reduce side effects and need for ongoing therapy
June 10, 2014, Mail Online
Game Changer for Leukemia Therapy
June 10, 2014, Newswise
Differential regulation of myeloid leukemias by the bone marrow microenvironment.
November 19, 2103, PubLmed
Bone Drug Kills Leukemia in Mice
November 1, 2013, Bioscience Technology
Evicting Leukemia - Bone drug kills resistant cancer stem cells by making home unlivable
October 31, 2013, Harvard medical school
Ottawa researchers hopeful nano-particles can cure leukemia VIDEO
August 13, 2013, CTV News
Leukemia–going for the cure!
July 29, 2013, ExpertClick
Perspective: Combined forces
June 27, 2013, Nature
Experimental Cancer Treatment Offers Hope VIDEO
March 21, 2013, ABCNews
Cell-Based Immune Therapy Shows Promise in Leukemia Patients
March 20, 2013, Memorial Sloan-Kettering Cancer Center
Could An Asthma Medicine Stop CML? VIDEO
February 4, 2013, Patient Power
Sabutoclax (ONT-701) May BeThe Next Magic Bullet To Combat The Root Of Cancer
January 30 2013, Science 2.0
Pan–BCL-2 Inhibition Sensitizes Leukemic Stem Cells to Kinase Inhibitors
January 24, 2013, Cancer Discovery
Sabutoclax appears to selectively target leukemia stem cells that are responsible for relapses
January 18, 2013, News Medical
Sanford-Burnham cancer drug targets hard-to-reach leukemia stem cells
January 18, 2013, Sanford Burnham
Bone Drug Kills Leukemia in Mice
January 11, 2013, BioScienceTechnology
A new enzyme that contributes to the proliferation of leukemia is discovered
December 26, 2012, Private MD News
How close are we to targeting the leukemia stem cell?
December 2012, Best Practice & Research Clinical Haematology
DNA-repair problems destroy hardy leukemia cells
December 26, 2012, OncologyNurseAdvisor
Reprogramming enzyme promotes chronic myeloid leukemia
Decenber 25, 2012, Omglobe.com
Enzyme accelerates malignant stem cell cloning in chronic myeloid leukemia
December 24, 2012, Eurekalert
Latest Treatment and Research for Chronic Myeloid Leukemia
December 24, 2012, Cancer Network
Sabutoclax, a Novel Pan BCL2 Family Inhibitor, Sensitizes Dormant Blast Crisis Chronic Myeloid Leukemia Stem Cells to Dasatinib
December 10, 2012, ASH 2012
RAD52-Dependent Synthetic Lethality Eradicates Leukemia Stem Cells
December 9, 2012, ASH 2012
Temple scientists target DNA repair to eradicate leukemia stem cells
December 9, 2012, MedicalXpress
Foreseeing a Cure for CML VIDEO
September 25, 2012, Patient Power
New breakthrough gives hope to cancer sufferers
July 10, 2012, ABC News
New blood cancer treatment to be tested
July 10, 2012, AdelaideNow
Drug may avert chemo side effects
July 10, 2012, The Age National
New Target Discovered Deep Within Cancer Cells
July 9, 2012, Science Daily
Methods for Detection and Elimination of Dormant Cancer Stem Cells
June 19, 2012, IBridge
Biomarker to Enable Eradication of CML Stem Cells
June 14, 2012, Ibridge
March 21, 2015, MailOnline
Effects of quercetin on hedgehog signaling in chronic myeloid leukemia KBM7 cells
October 24, 2014, PublMed
The BCL2 inhibitor ABT-199 significantly enhances imatinib-induced cell death in chronic myeloid leukemia progenitors.
October 15, 2014, PublMed
SL-401 and SL-501, targeted therapeutics directed at the interleukin-3 receptor, inhibit the growth of leukaemic cells and stem cells in advanced phase chronic myeloid leukaemia
June 19, 2014, British Journal of Haematology
JAK2/STAT5 inhibition by nilotinib with ruxolitinib contributes to the elimination of chronic phase CML CD34+ cells in vitro and in vivo
June 16, 2014, Journal Blood
New discovery could soon make leukemia history
June 11, 2014, Business Standard
Breakthrough in cancer research as treatment is developed that gets cancer cells to kill themselves: 'Paradigm-shifting' discovery will DRAMATICALLY reduce side effects and need for ongoing therapy
June 10, 2014, Mail Online
Game Changer for Leukemia Therapy
June 10, 2014, Newswise
Differential regulation of myeloid leukemias by the bone marrow microenvironment.
November 19, 2103, PubLmed
Bone Drug Kills Leukemia in Mice
November 1, 2013, Bioscience Technology
Evicting Leukemia - Bone drug kills resistant cancer stem cells by making home unlivable
October 31, 2013, Harvard medical school
Ottawa researchers hopeful nano-particles can cure leukemia VIDEO
August 13, 2013, CTV News
Leukemia–going for the cure!
July 29, 2013, ExpertClick
Perspective: Combined forces
June 27, 2013, Nature
Experimental Cancer Treatment Offers Hope VIDEO
March 21, 2013, ABCNews
Cell-Based Immune Therapy Shows Promise in Leukemia Patients
March 20, 2013, Memorial Sloan-Kettering Cancer Center
Could An Asthma Medicine Stop CML? VIDEO
February 4, 2013, Patient Power
Sabutoclax (ONT-701) May BeThe Next Magic Bullet To Combat The Root Of Cancer
January 30 2013, Science 2.0
Pan–BCL-2 Inhibition Sensitizes Leukemic Stem Cells to Kinase Inhibitors
January 24, 2013, Cancer Discovery
Sabutoclax appears to selectively target leukemia stem cells that are responsible for relapses
January 18, 2013, News Medical
Sanford-Burnham cancer drug targets hard-to-reach leukemia stem cells
January 18, 2013, Sanford Burnham
Bone Drug Kills Leukemia in Mice
January 11, 2013, BioScienceTechnology
A new enzyme that contributes to the proliferation of leukemia is discovered
December 26, 2012, Private MD News
How close are we to targeting the leukemia stem cell?
December 2012, Best Practice & Research Clinical Haematology
DNA-repair problems destroy hardy leukemia cells
December 26, 2012, OncologyNurseAdvisor
Reprogramming enzyme promotes chronic myeloid leukemia
Decenber 25, 2012, Omglobe.com
Enzyme accelerates malignant stem cell cloning in chronic myeloid leukemia
December 24, 2012, Eurekalert
Latest Treatment and Research for Chronic Myeloid Leukemia
December 24, 2012, Cancer Network
Sabutoclax, a Novel Pan BCL2 Family Inhibitor, Sensitizes Dormant Blast Crisis Chronic Myeloid Leukemia Stem Cells to Dasatinib
December 10, 2012, ASH 2012
RAD52-Dependent Synthetic Lethality Eradicates Leukemia Stem Cells
December 9, 2012, ASH 2012
Temple scientists target DNA repair to eradicate leukemia stem cells
December 9, 2012, MedicalXpress
Foreseeing a Cure for CML VIDEO
September 25, 2012, Patient Power
New breakthrough gives hope to cancer sufferers
July 10, 2012, ABC News
New blood cancer treatment to be tested
July 10, 2012, AdelaideNow
Drug may avert chemo side effects
July 10, 2012, The Age National
New Target Discovered Deep Within Cancer Cells
July 9, 2012, Science Daily
Methods for Detection and Elimination of Dormant Cancer Stem Cells
June 19, 2012, IBridge
Biomarker to Enable Eradication of CML Stem Cells
June 14, 2012, Ibridge
Identification of Drugs Including a Dopamine Receptor Antagonist that Selectively Target Cancer Stem Cells
May 24, 2012, Cell
Looking for tools to shut down leukemia for good
May 1, 2012, City of Hope
Altered Microenvironmental Regulation of Leukemic and Normal Stem Cells in Chronic Myelogenous Leukemia
April 17, 2012, Cancer Cell
May 24, 2012, Cell
Looking for tools to shut down leukemia for good
May 1, 2012, City of Hope
Altered Microenvironmental Regulation of Leukemic and Normal Stem Cells in Chronic Myelogenous Leukemia
April 17, 2012, Cancer Cell
Chronic Myeloid Leukemia: Are We Close to Finding a Cure?
February 23, 2012, American Health & Drug Benefits
Therapy targets leukemia stem cells
February 13, 2012, Eurekalert
HIF1α is required for survival maintenance of chronic myeloid leukemia stem cells
January 24, 2012, Journal Blood
Why Does It Take So Long To Go from Mouse to Man?
January 1, 2012, Quest
Phase 1 Clinical Trial of KB004 in EphA3-Expressing Hematologic Malignancies
January 2012, Monash University
Possible cure for CML in Fish Oil
December 22, 2011, CMLeukemia
Minimal Residual Disease and Discontinuation of Therapy in Chronic Myeloid Leukemia: Can We Aim at a Cure?
December 10, 2011, Hematology
Canadian researchers find potential new leukemia treatment with old antibiotic drug
November 20. 2011, Canadian Biotechnologist 2.0
The End of Cancer. DCA makes its world debut.
May 22, 2011, Arbitrage Magasine
CML biology for the clinician in 2011: six impossible things to believe before breakfast on the way to cure
2011, Vol18, No 4, Current Oncology
Leukemia Stem Cells - Will rapamycin work in people with leukemia?
March 2011, University of Michigan
New approach to leukemia chemotherapy -- is a cure in sight?
March 30, 2011, ScienceDaily
Hematology: Curing CML with imatinib—a dream come true?
February 1, 2011, Nature Reviews Clinical Oncology
Safety of Zileuton (Zyflo) in Combination With Imatinib Mesylate (Gleevec) in CML
September 2010, ClincalTrials.gov
Target of Rapamycin Signaling in Leukemia and Lymphoma
September 8, 2010, Clinical cancer Research
Isolation and killing of candidate chronic myeloid leukemia stem cells by antibody targeting of IL-1 receptor accessory protein
August 30, 2010, PubMed Central
Eradicating The CML stem cell
June 2010, University of Turin, Italy
Combination Therapy Targets Stubborn Leukemia Stem Cells
May 17,2010, Science Daily
Effective Targeting of Quiescent Chronic Myelogenous Leukemia Stem Cells by Histone Deacetylase Inhibitors in Combination with Imatinib Mesylate
March 11, 2010, Cancer Cell
Vaccine may cure chronic myeloid leukemia CML
January 10, 2010, Health Newstrack
Irish scientists ‘close to finding leukaemia cure’
November 24, 2009, Belfast Telegraph
Irish leukaemia drug trials 'promising'
November 23, 2009, RTÉ News
Adelaide researchers on road to myeloid leukemia cure
October 2009, NEWS.COM.AU
Cure possible for one type of leukemia
September 2009, Bangor Daily News
Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia
July 2009, Nature Genetics Volume 41 Number7
Scientists Identify Molecular Signature For Leukemia Stem Cells
March 2009, Medical News Today
The leukemic stem cell
2008, NCBI
Can we cure CML?
April 15, 2004, Blood Journal
February 23, 2012, American Health & Drug Benefits
Therapy targets leukemia stem cells
February 13, 2012, Eurekalert
HIF1α is required for survival maintenance of chronic myeloid leukemia stem cells
January 24, 2012, Journal Blood
Why Does It Take So Long To Go from Mouse to Man?
January 1, 2012, Quest
Phase 1 Clinical Trial of KB004 in EphA3-Expressing Hematologic Malignancies
January 2012, Monash University
Possible cure for CML in Fish Oil
December 22, 2011, CMLeukemia
Minimal Residual Disease and Discontinuation of Therapy in Chronic Myeloid Leukemia: Can We Aim at a Cure?
December 10, 2011, Hematology
Canadian researchers find potential new leukemia treatment with old antibiotic drug
November 20. 2011, Canadian Biotechnologist 2.0
The End of Cancer. DCA makes its world debut.
May 22, 2011, Arbitrage Magasine
CML biology for the clinician in 2011: six impossible things to believe before breakfast on the way to cure
2011, Vol18, No 4, Current Oncology
Leukemia Stem Cells - Will rapamycin work in people with leukemia?
March 2011, University of Michigan
New approach to leukemia chemotherapy -- is a cure in sight?
March 30, 2011, ScienceDaily
Hematology: Curing CML with imatinib—a dream come true?
February 1, 2011, Nature Reviews Clinical Oncology
Safety of Zileuton (Zyflo) in Combination With Imatinib Mesylate (Gleevec) in CML
September 2010, ClincalTrials.gov
Target of Rapamycin Signaling in Leukemia and Lymphoma
September 8, 2010, Clinical cancer Research
Isolation and killing of candidate chronic myeloid leukemia stem cells by antibody targeting of IL-1 receptor accessory protein
August 30, 2010, PubMed Central
Eradicating The CML stem cell
June 2010, University of Turin, Italy
Combination Therapy Targets Stubborn Leukemia Stem Cells
May 17,2010, Science Daily
Effective Targeting of Quiescent Chronic Myelogenous Leukemia Stem Cells by Histone Deacetylase Inhibitors in Combination with Imatinib Mesylate
March 11, 2010, Cancer Cell
Vaccine may cure chronic myeloid leukemia CML
January 10, 2010, Health Newstrack
Irish scientists ‘close to finding leukaemia cure’
November 24, 2009, Belfast Telegraph
Irish leukaemia drug trials 'promising'
November 23, 2009, RTÉ News
Adelaide researchers on road to myeloid leukemia cure
October 2009, NEWS.COM.AU
Cure possible for one type of leukemia
September 2009, Bangor Daily News
Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia
July 2009, Nature Genetics Volume 41 Number7
Scientists Identify Molecular Signature For Leukemia Stem Cells
March 2009, Medical News Today
The leukemic stem cell
2008, NCBI
Can we cure CML?
April 15, 2004, Blood Journal
Surviving CML pre-imatinib era
In 1981, Dr. Robert Patenaude from Quebec (Canada) was diagnosed with CML. He has gone through a bone marrow transplant in 1982, when he was a second-year medical student. He wrote a book Surviving Leukemia: A Practical Guide (Your Personal Health) . After 30 years, he didn’t relapse. See this article, 30 years of victory against cancer. If you understand French, you can see some videos featuring Dr Robert Patenaude
In 1981, Dr. Robert Patenaude from Quebec (Canada) was diagnosed with CML. He has gone through a bone marrow transplant in 1982, when he was a second-year medical student. He wrote a book Surviving Leukemia: A Practical Guide (Your Personal Health) . After 30 years, he didn’t relapse. See this article, 30 years of victory against cancer. If you understand French, you can see some videos featuring Dr Robert Patenaude
