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    • Team of experts on CML who developed imatinib >
      • Dr. Elisabeth Buchdunger
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    • Experts involved in developing dasatinib >
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    • CML experts in America >
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        • How to get the CMLer's password?
        • Dr. Sarit Assouline
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      • CML experts in US >
        • How to get the CMLer's password?
        • Carolyn Blasdel, RN , FNP-BC, OCN
        • Rey Garcia, RN, BSN
        • PATRICIA JAKEL, RN, MN, AOCN
        • Dr. Charles Schiffer
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      • CML experts in South America >
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    • CML Experts in Europe >
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        • Pr Gregor Verhoef
      • CML expert in France >
        • Comment obtenir le mot de passe?
        • Dr. François-Xavier Mahon
        • Dr Aude Charbonnier
        • Dr. Agnès Guerci Bresler
        • Dr Pascale Cony-Makhoul
        • Dr. Delphine Rea
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        • Dre Célia SALANOUBAT
        • Pr. Mauricette Michallet
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      • CML expert in Italy >
        • Dr. Carlo Gambacorti-Passerini
        • Dr. Chiara Elena
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      • CML expert in UK >
        • Dr. Jane Apperley
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      • CML expert in Germany >
        • Dr. Andreas Hochhaus
        • Professor Jörg Hasford
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        • Dr Susanne Saussele
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      • CML expert in Portugal >
        • Dr. Antônio Medina de Almeida
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        • Dr. Juan Luis Steegmann
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        • Dr. Jeroen J.W.M. Janssen
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        • Dr. Johan Richter
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        • Dr. Hana Klamova
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      • Dr. Annuar Rapaee
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    • CML experts in Africa >
      • Dr. Asmaa Quessar
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  • Medical Concepts
    • How to get the CMLer's password?
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    • List of side effets >
      • How to get the CMLer's password?
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  • Patient Testimonials
    • How to get the CMLer's password?
    • 30 years and plus survivors >
      • How to get the CMLer's password?
      • Mark Popadick
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    • 20 years and plus survivors >
      • How to get the CMLer's password?
      • Doug Jenson
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    • 10 years and plus survivors >
      • How to get the CMLer's password?
      • Dan Sloan
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      • How to get the CMLer's password?
      • Skye Davidson
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      • How to get the CMLer's password?
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    • Blogs >
      • How to get the CMLer's password?
      • Living with CML
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      • Blogs not recently updated >
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  • Cure possible for CML?
    • How to get the CMLer's password?
    • Hematopoietic stem cell transplantation using single UM171-expanded cord blood >
      • Greffe de cellules souches de cordon ombilical amplifiées par la molécule UM171
    • Combination of tyrosine kinase inhibitor with other medication >
      • Combinaison of hydroxychloroquine with tyrosine kinase inhibitor
      • Combination of ruxolitinib with tyrosine kinase inhibitor
      • Combination of insulin sensitizer MSDC-0600K with tyrosine kinase inhibitor
      • Combination of miristen with tyrosine kinase inhibitor
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    • Inhibitory effect of c-Myc on p53-induced apoptosis in leukemia cells
    • Inhibition of the protein Ezh2 can cure CML?
    • Inhibition of STAT5 in conjunction with standard TKI therapy
    • PROTAC-mediated Targeted Protein Degradation
    • CML vaccine
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    • Could fasting cure chronic myeloid leukemia
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    • Can genetic sequencing help to cure leukemia?
    • Can the new drug CX-5461 cure leukemia?
    • CRISPR-Cas9 gene-editing technique
    • Presence of bcr abl fusion transcripts in healthy individua
    • Math could help cure leukemia
    • Natural Medicine >
      • Possible cure for CML in Fish Oil
      • Betel leaf may help fight CML
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      • Can dandelions kill cancer?
      • Can curcumin cure leukemia?
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Chronic Myeloid Leukemia

 Dr. Stephen G O'Brien - CML - Chronic myeloid leukemia


" Stephen O'Brien is a Professor of Haematology at Newcastle University and Honorary Consultant in Haematology at the Newcastle upon Tyne Hospitals NHS Foundation Trust. Following graduation and internal medical experience in Manchester, his training in haematology was undertaken at the Hammersmith Hospital in London where he subsequently completed his PhD under Professor John Goldman. He then worked in Cardiff before settling in Newcastle. He treated the first UK patients to receive Imatinib in September 1999, and continues to be closely involved with ongoing trials with this agent, as well as the newer Tyrosine Kinase Inhibitors. Professor O’Brien is the Chief Investigator for the National Cancer Research Network’s SPIRIT trials in Chronic Myeloid Leukaemia (www.spirit-cml.org), involving approximately 2,000 patients in 150 UK hospitals. Also, he is a member of the NCRI Haem Onc Clinical Studies Group and CML Working Party and the European Leukaemia Network and Vice Chair of NICE Technology Appraisal Committee C."
​Extract of  Northern Institute for Cancer Research, Newcastle University

​


Other links:    Stephen G O'Brien's scientific contributions while affiliated with Newcastle University 
                              Some publications with Dr. G O'Brien
                             
Some presentations and notes from ASH meetings

​                                       

VIDEOS

Outlook for the management of chronic myeloid leukemia
July 10, 2015,  VJHemOnc – Video Journal of Hematological Oncology


ARTICLES
​

Chronic myeloid leukemia: an overview of data from American Society of Hematology 2014
November 21, 2014, Rev Hematol Mex

Effects of imatinib mesylate (STI571, Glivec) on the pharmacokinetics of simvastatin, a cytochrome p450 3A4 substrate, in patients with chronic myeloid leukaemia.
November 17, 2003, Pubmed
​
Imatinib in patients with newly diagnosed chronic-phase chronic myeloid leukemia.
April 2003, Pubmed

Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia
March 13, 2003, Pubmed
​
Position paper on imatinib mesylate in chronic myeloid leukaemia
October 2, 2002, British Journal Of Haematology

Chronic myelogenous leukemia
January 1, 2002, ASH education book


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