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    • Team of experts on CML who developed imatinib >
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        • How to get the CMLer's password?
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        • Comment obtenir le mot de passe?
        • Dr. François-Xavier Mahon
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  • Cure possible for CML?
    • How to get the CMLer's password?
    • Hematopoietic stem cell transplantation using single UM171-expanded cord blood >
      • Greffe de cellules souches de cordon ombilical amplifiées par la molécule UM171
    • Combination of tyrosine kinase inhibitor with other medication >
      • Combinaison of hydroxychloroquine with tyrosine kinase inhibitor
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    • Inhibitory effect of c-Myc on p53-induced apoptosis in leukemia cells
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      • Possible cure for CML in Fish Oil
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Chronic Myeloid Leukemia

Hematopoietic stem cell transplantation using single UM171-expanded cord blood
                         CML - Chronic myeloid leukemia

                                                                                                                                       Français
''Benefits of cord blood transplantation include low rates of relapse and chronic graft-versus-host disease (GVHD). However, the use of cord blood is rapidly declining because of the high incidence of infections, severe acute GVHD, and transplant-related mortality. UM171, a haematopoietic stem cell self-renewal agonist, has been s​hown to expand cord blood stem cells and enhance multilineage blood cell reconstitution in mice. We aimed to investigate the safety and feasibility of single UM171-expanded cord blood transplantation in patients with haematological malignancies who do not have a suitable HLA-matched donor.''
​Extract of  
Hematopoietic stem cell transplantation using single UM171-expanded cord blood: a single-arm, phase 1–2 safety and feasibility study
"In their new study, the IRIC researchers found to their great surprise that UM171 is able to act as a veritable “fountain of youth” for blood stem cells. Three days after administration of the molecule, the stem cells presented an epigenome similar to the initial young cord-blood cells, whereas in the absence of UM171, these cells underwent premature epigenome aging.
As a result, patients transplanted with the rejuvenated cells very quickly experience an overall improvement in their quality of life as their blood cell counts are rapidly recovered. Not only does UM171 rejuvenate the cells, they also become more competent at producing an improved immune system. As a result, after six months, most patients no longer need immunosuppressants, normally needed to reverse the negative immunological impact of bone-marrow transplants."
Extract of UM171: the molecule that keeps on giving


VIDEOS

UM171 improves outcomes of cord-blood transplants in high-risk leukemia
December 22, 2023, VJHemOnc – Video Journal of Hematology & HemOnc


IRIC: Molecule UM171, an historic discovery

May 26, 2015, Campus Montréal

 
Unlocking Cord Blood
September 9, 2014, stemcellfoundation

Vanquishing cancer differently - Institute for Research in Immunology and Cancer (IRIC)
May 27, 2014,  IRIC umontreal


CLINICAL TRIALS

US Study of UM171-Expanded CB in Patients With High Risk Leukemia/Myelodysplasia
Fred Hutchinson / University of Washington Cancer Consortium
Seattle, Washington, United States

Expanded Cord Blood in Patients in Need of an Allogeneic Stem Cell Transplant
​Hopital Maisonneuve-Rosemont
Montreal, Quebec, Canada
                           More clinical trials for UM171
PUBLICATIONS
​

The stem cell–supporting small molecule UM171 triggers Cul3-KBTBD4–mediated degradation of ELM2 domain–harboring proteins
May 2023, Journal of Biological Chemistry


Umbilical cord blood transplantation: Still growing and improving
November 1, 2021, Stem Cells Translational Medicine


UM171-Expanded Cord Blood Transplants Support Robust T Cell Reconstitution with Low Rates of Severe Infections
January 2021, Cord Blood, Volume 27


UM171 Enhances Lentiviral Gene Transfer and Recovery of Primitive Human Hematopoietic Cells
September 2018, Molecular Therapy: Methods & Clinical Development


Single UM171 expanded cord blood transplant is feasible and safe, accelerates engraftment, reduces hospitalization length and most importantly improves HLA matching
September 2017, Experimental Hematology


Pyrimidoindole derivative UM171 enhances derivation of hematopoietic progenitor cells from human pluripotent stem cells
May 2017, Stem Cell Research

Discovery May Hike Stem Cell Transplants
December 2014, Cancer Discovery

​
ARTICLES
 
Take the MYC to expand blood stem cells
March 7, 2024, Blood


UM171 Expansion of Cord Blood Improves Donor Availability and HLA Matching For All Patients, Including Minorities

March 18, 2022, Science Direct


Cord-Blood Engraftment Using an Enhanced Dual-Conditioning Regimen for Malignant Hematologic Diseases
January 25, 2022 , Sage Journals


Cord blood expansion has arrived
October 21, 2021, Blood         
    

AABB NEWS: DREAMS OF EXPANSION
July 20, 2021, AABB


Evaluation of a clinical-grade, cryopreserved, ex vivo-expanded stem cell product from cryopreserved primary umbilical cord blood demonstrates multilineage hematopoietic engraftment in mouse xenografts
May 19, 2021, Cytotherapy


Cord Blood Transplantation: State of the Science
March 2021, Cord Blood Association


UM171: the molecule that keeps on giving
January 12, 2021,  Udem Nouvelles


UM171 Preserves Epigenetic Marks that Are Reduced in Ex Vivo Culture of Human HSCs via Potentiation of the CLR3-KBTBD4 Complex
January 7, 2021, PubMed


Lysine-specific demethylase 1A restricts ex vivo propagation of human HSCs and is a target of UM171
November 5, 2020, Blood


Blood cancer: World premiere at Hôpital Maisonneuve-Rosemont
October 8, 2020, FHMR


Hematopoietic stem cell transplantation using single UM171-expanded cord blood
October 3, 2020, ASTCT


Umbilical Cord Blood Transplants: Current Status and Evolving Therapies
October 2, 2020, Frontiers in Pediatrics


Autoimmune disease: UM171 saves another life
September 30, 2020,  Science Daily


Single UM171‐Expanded Cord Blood Transplants Support Robust T‐Cell Reconstitution with Low Rates of Severe Infections
September 9, 2020, Stem Cells


Single UM171-expanded cord blood transplant can cure severe idiopathic aplastic anemia in absence of suitable donors
August 4, 2020, European Journal of Haematology


UM171 induces a homeostatic inflammatory-detoxification response supporting human HSC self-renewal
November 8, 2019, Plos One


Hematopoietic stem cell transplantation using single UM171-expanded cord blood: a single-arm, phase 1–2 safety and feasibility study
November 6, 2019, The Lancet Heamatology

Blood cancers: New generation stem cell transplant significantly reduces complications for patients
November 5, 2019, Université of Montreal


UM171 expands distinct types of myeloid and NK progenitors from human pluripotent stem cells
April 29, 2019, Nature.com

UM171 Molecule: Completion of Phase I/II clinical trial for the treatment of blood cancer patients
June 27, 2018, IRIC


Researchers develop molecule that boosts cord blood stem cells
September 18, 2014, CTV news



​                                               See also Cure possible  for CML?

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