Hematopoietic stem cell transplantation using single UM171-expanded cord blood
CML - Chronic myeloid leukemia
''Benefits of cord blood transplantation include low rates of relapse and chronic graft-versus-host disease (GVHD). However, the use of cord blood is rapidly declining because of the high incidence of infections, severe acute GVHD, and transplant-related mortality. UM171, a haematopoietic stem cell self-renewal agonist, has been shown to expand cord blood stem cells and enhance multilineage blood cell reconstitution in mice. We aimed to investigate the safety and feasibility of single UM171-expanded cord blood transplantation in patients with haematological malignancies who do not have a suitable HLA-matched donor.''
Extract of Hematopoietic stem cell transplantation using single UM171-expanded cord blood: a single-arm, phase 1–2 safety and feasibility study
VIDEOS
IRIC: Molecule UM171, an historic discovery
May 26, 2015, Campus Montréal
Unlocking Cord Blood
September 9, 2014, stemcellfoundation
Vanquishing cancer differently - Institute for Research in Immunology and Cancer (IRIC)
May 27, 2014, IRIC umontreal
IRIC: Molecule UM171, an historic discovery
May 26, 2015, Campus Montréal
Unlocking Cord Blood
September 9, 2014, stemcellfoundation
Vanquishing cancer differently - Institute for Research in Immunology and Cancer (IRIC)
May 27, 2014, IRIC umontreal
CLINICAL TRIALS
US Study of UM171-Expanded CB in Patients With High Risk Leukemia/Myelodysplasia
Fred Hutchinson / University of Washington Cancer Consortium
Seattle, Washington, United States
Expanded Cord Blood in Patients in Need of an Allogeneic Stem Cell Transplant
Hopital Maisonneuve-Rosemont
Montreal, Quebec, Canada
US Study of UM171-Expanded CB in Patients With High Risk Leukemia/Myelodysplasia
Fred Hutchinson / University of Washington Cancer Consortium
Seattle, Washington, United States
Expanded Cord Blood in Patients in Need of an Allogeneic Stem Cell Transplant
Hopital Maisonneuve-Rosemont
Montreal, Quebec, Canada
PUBLICATIONS
UM171 Enhances Lentiviral Gene Transfer and Recovery of Primitive Human Hematopoietic Cells
September 2018, Molecular Therapy: Methods & Clinical Development
Single UM171 expanded cord blood transplant is feasible and safe, accelerates engraftment, reduces hospitalization length and most importantly improves HLA matching
September 2017, Experimental Hematology
Pyrimidoindole derivative UM171 enhances derivation of hematopoietic progenitor cells from human pluripotent stem cells
May 2017, Stem Cell Research
UM171 Enhances Lentiviral Gene Transfer and Recovery of Primitive Human Hematopoietic Cells
September 2018, Molecular Therapy: Methods & Clinical Development
Single UM171 expanded cord blood transplant is feasible and safe, accelerates engraftment, reduces hospitalization length and most importantly improves HLA matching
September 2017, Experimental Hematology
Pyrimidoindole derivative UM171 enhances derivation of hematopoietic progenitor cells from human pluripotent stem cells
May 2017, Stem Cell Research
ARTICLES
Lysine-specific demethylase 1A restricts ex vivo propagation of human HSCs and is a target of UM171
November 5, 2020, Blood
Autoimmune disease: UM171 saves another life
September 30, 2020, Science Daily
Single UM171‐Expanded Cord Blood Transplants Support Robust T‐Cell Reconstitution with Low Rates of Severe Infections
September 9, 2020, Stem Cells
UM171 induces a homeostatic inflammatory-detoxification response supporting human HSC self-renewal
November 8, 2019, Plos One
Hematopoietic stem cell transplantation using single UM171-expanded cord blood: a single-arm, phase 1–2 safety and feasibility study
November 6, 2019, The Lancet Heamatology
Blood cancers: New generation stem cell transplant significantly reduces complications for patients
November 5, 2019, Université of Montreal
UM171 expands distinct types of myeloid and NK progenitors from human pluripotent stem cells
April 29, 2019, Nature.com
UM171 Molecule: Completion of Phase I/II clinical trial for the treatment of blood cancer patients
June 27, 2018, IRIC
Lysine-specific demethylase 1A restricts ex vivo propagation of human HSCs and is a target of UM171
November 5, 2020, Blood
Autoimmune disease: UM171 saves another life
September 30, 2020, Science Daily
Single UM171‐Expanded Cord Blood Transplants Support Robust T‐Cell Reconstitution with Low Rates of Severe Infections
September 9, 2020, Stem Cells
UM171 induces a homeostatic inflammatory-detoxification response supporting human HSC self-renewal
November 8, 2019, Plos One
Hematopoietic stem cell transplantation using single UM171-expanded cord blood: a single-arm, phase 1–2 safety and feasibility study
November 6, 2019, The Lancet Heamatology
Blood cancers: New generation stem cell transplant significantly reduces complications for patients
November 5, 2019, Université of Montreal
UM171 expands distinct types of myeloid and NK progenitors from human pluripotent stem cells
April 29, 2019, Nature.com
UM171 Molecule: Completion of Phase I/II clinical trial for the treatment of blood cancer patients
June 27, 2018, IRIC
