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  • CML Experts
    • Team of experts on CML who developed imatinib >
      • Dr. Elisabeth Buchdunger
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        • How to get the CMLer's password?
        • Dr. Sarit Assouline
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        • How to get the CMLer's password?
        • Carolyn Blasdel, RN , FNP-BC, OCN
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        • Pr Gregor Verhoef
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        • Comment obtenir le mot de passe?
        • Dr. François-Xavier Mahon
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      • CML expert in Italy >
        • Dr. Carlo Gambacorti-Passerini
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      • CML expert in UK >
        • Dr. Jane Apperley
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      • CML expert in Germany >
        • Dr. Andreas Hochhaus
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        • Dr Susanne Saussele
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      • CML expert in Portugal >
        • Dr. Antônio Medina de Almeida
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        • Dr. Jeroen J.W.M. Janssen
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        • Dr. Hana Klamova
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  • Medical Concepts
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  • Medication
    • How to get the CMLer's password?
    • Hydroxyurea
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  • Managing side effects
    • List of side effets >
      • How to get the CMLer's password?
      • Acid Uric - Gout
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    • Complementary and Alternative Medicine >
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        • Debussy – Relaxing music - Clair de lune et autres...
        • Delicate music for the soul and LIFE, and birdsong soothes the nervous system.
        • Adagio for Strings (Samuel Barber)
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        • The song "Disenchanted'
      • Yoga
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  • Patient Testimonials
    • 30 years and plus survivors >
      • How to get the CMLer's password?
      • Mark Popadick
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    • 20 years and plus survivors >
      • How to get the CMLer's password?
      • Doug Jenson
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    • 10 years and plus survivors >
      • How to get the CMLer's password?
      • Dan Sloan
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      • Kayla Naton (Pregnancy)
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    • New CMLers >
      • How to get the CMLer's password?
      • Skye Davidson
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    • Celebrities with CML >
      • How to get the CMLer's password?
      • Alexa Score
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      • Greg Lemond
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    • Suzan Mc Namara and the petition
    • Bud Romine - the first patient
    • Other testimonials
    • Blogs >
      • How to get the password?
      • Living with CML
      • Michelle D's Blog
      • Jon's Blog
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      • Blogs not recently updated >
        • Access CML Drugs
        • CMKID's blog – Dislodging the bullet - 2012
        • CML Recovery - Stopping KTI -2011
        • Hans's Blog -2012
        • Elizabeth's Blog - my leukemia - 2013journey
        • Elizabeth's Blog - Heart of the rose -2011
        • Joe's Blog - 2012
        • Josh's Blog - 2014
        • Mannan's Blog -2014
        • Ian's Blog -2014
        • Matt's Blog - 2012
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  • Global News on CML
    • English - Latest CML News >
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  • Various topics
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    • CML patients and the coronavirus
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    • Pronostic, life expectancy, quality of life, ..... in chronic myeloid leukemia
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    • CML Awareness Day >
      • Journée mondiale de sensibilisation à la leucémie myéloïde chronique
    • The movie "Dying to Survive"
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  • Cure possible for CML?
    • How to get the CMLer's password?
    • Hematopoietic stem cell transplantation using single UM171-expanded cord blood >
      • Greffe de cellules souches de cordon ombilical amplifiées par la molécule UM171
    • Combination of tyrosine kinase inhibitor with other medication >
      • Combinaison of hydroxychloroquine with tyrosine kinase inhibitor
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      • Combination of miristen with tyrosine kinase inhibitor
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    • Inhibitory effect of c-Myc on p53-induced apoptosis in leukemia cells
    • Inhibition of the protein Ezh2 can cure CML?
    • Inhibition of STAT5 in conjunction with standard TKI therapy
    • PROTAC-mediated Targeted Protein Degradation
    • CML vaccine
    • Can immunotherapy cure leukemia?
    • Could fasting cure chronic myeloid leukemia
    • Chimeric Antigen Receptor T-Cell Therapy
    • Can genetic sequencing help to cure leukemia?
    • Can the new drug CX-5461 cure leukemia?
    • CRISPR-Cas9 gene-editing technique
    • Presence of bcr abl fusion transcripts in healthy individua
    • Math could help cure leukemia
    • Natural Medicine >
      • Possible cure for CML in Fish Oil
      • Betel leaf may help fight CML
      • Feverfew extract (parthenolide)
      • Can dandelions kill cancer?
      • Can curcumin cure leukemia?
  • Treatment free remission(TFR)
    • The French trial called STIM (Stop Imatinib)
    • De-escalation of treatment
    • Tyrosine Kinase Inhibitor Withdrawal Syndrome in CML Patients
  • Educational videos (all languages)
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  • Congresses, conferences, meetings ASH, ASCO, EHA ...
    • ASCO - American Society of Clinical Oncology >
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Chronic Myeloid Leukemia

Children with Chronic Myeloid Leukemia -   CML

SITES

International CML Foundation - Section on Pediatric CML  

Junior CML Advocates
Children with cancer (UK)
Registration of Children With CML and Treatment With Imatinib (CML-paed II)   
Seattle Cancer Care Alliance – Pediatrics (US)
Children's Hospital Boston
The International BFM Study Group
Aaron Bullingham’s site
Isabella Juliette Babione’s site
Medical Resources: Understanding Leukemia by Online Nursing Degrees
FORUMS

Children with CML by CML Support (UK)  
                                           -----------------------
Children with CML in Facebook  (new group)   (old group)
Mary Sullivan 2 years old  -  story in Facebook
"If you or a family member has been diagnosed with a blood cancer, you may find it helpful to speak with someone who has gone through a similar experience and learned how to manage the same disease you're trying to cope with each day. The Patti Robinson Kaufmann First Connection Program is a free service of The Leukemia & Lymphoma Society (LLS) that matches patients and their loved ones with trained peer volunteers who have shared similar experiences.
Extract of Peer-to-peer Support - The Leukemia & Lymphoma Society (LLS)
CLINICAL TRIALS

INCB84344-102 = Safety and efficacy of ponatinib for recurrent or refractory leukemias or solid tumors in children [Europe]

BCHILD - Bosutinib in Pediatric Patients [Denmark, France, Germany, Ireland, Israel, Italy, Netherlands, Spain, Switzerland, UK]
                        Other clinical trials with children
VIDEOS
​
EHA 2019: Special aspects in children (Fréderic Millot) -Mechanisms for Resistance and TFR in CML: Special Aspects in Children
2020, iCMLf
​
Pediatric CML
November 2019, iCMLf
​
New findings on the Philadelphia chromosome
September 17, 2018, UFHealth

​
​The Bone Marrow - Factory of Life (for children)
November 22, 2011, sodasystem

Cancer survivors beat the odds, graduate high school     
June 19, 2011, Today
 
​Believe in tomorrow    
​September 4, 2008, believeintomorrow
​
Katie's story: age 6
Dylan's story: age 9 
Katie's story: age 22
Rob's story:  age 22

​
ARTICLES

Tyrosine Kinase Inhibitor Discontinuation Safe in Pediatric Chronic Myeloid Leukemia
September 22, 2022,  Cancer Therapy Advisor
​
Outcome of pediatric chronic myeloid leukemia with management focusing on the monitoring of BCR-ABL fusion gene transcript levels
June 2, 2022, NCBI

​Factors That Impact HRQOL in Pediatric Patients With Chronic Myeloid Leukemia
November 16, 2021, Cancer Therapy Advisor

Long-term outcome of tyrosine kinase inhibitor treatment in children and adolescents with newly diagnosed chronic myeloid leukemia in chronic phase
July 22, 2021, Chinese Medical Journal

Patterns of surveillance for late effects of BCR-ABL tyrosine kinase inhibitors in survivors of pediatric Philadelphia chromosome positive leukemias
May 5, 2021, MDLinx

Discontinuation of Imatinib in Children with Chronic Myeloid Leukemia: An International Registry of Childhood Chronic Myeloid Leukemia (I-CML-Ped) Study
December 5, 2020, ASH2020

Vaccination With Live Attenuated Vaccines in Four Children With Chronic Myeloid Leukemia While on Imatinib Treatment
April 2020, Frontiers in Immunology

Sustained Molecular Response Following a Failed Attempt of Tyrosine Kinase Inhibitor Discontinuation & the Effects on Growth in a Child With Chronic Myeloid Leukemia: Not Always a Short Story
April 29, 2020, PubMed

Coronavirus: 'I'm self-isolating - but I have 26 pen pals’ – Teenager with CML'
March 22, 2020, BBC News

Pharmacokinetics of Nilotinib in Pediatric Patients with Philadelphia Chromosome–Positive Chronic Myeloid Leukemia or Acute Lymphoblastic Leukemia
March 3, 2020, Clinical Cancer Research

Results and outcome of intermittent imatinib (ON/OFF schedule) in children and adolescents with chronic myeloid leukaemia
February 22, 2020, BJH 
 
Experience with ponatinib in paediatric patients with leukaemia
January 24, 2020, BJH    

Nilotinib Therapy Safe, Effective for Certain Patients With CML
January 16, 2020, Oncology Learning Network

Acquired von Willebrand Syndrome in Pediatric Patients With Chronic Myeloid Leukemia
November 7, 2019, Hematology Advisor

Leukemia and Childhood Infection Hypothesis
Jul 30, 2019, News Medical

Risk of Hospitalization Remains High for Survivors of Childhood Leukemia
February 21, 2019, Oncology Nurse Advisor

Physiologically based pharmacokinetic modeling to supplement nilotinib pharmacokinetics and confirm
dose selection in pediatric patients
 
February 4, 2019
, PubMed

Addressing Off-Target Effects of TKIs in Pediatric CML
December 10, 2018, OncLive

Practice Patterns of Physician Treatment for Pediatric Chronic Myeloid Leukemia (CML)
September 26, 2018,  PubMed

Research Indicates Imatinib Is Effective in Pediatric Patients With Chronic Phase CML
July 19, 2018, Cancer Therapy Advisor

EC approves expanded indication for Sprycel
July 6, 2018, thepharmaletter

Dasatinib Approved in Europe for Pediatric Ph+ Chronic Phase CML
July 5, 2018,  OncLive

Front-line imatinib treatment in children and adolescents with chronic myeloid leukemia: results from a phase III trial
June 20, 2018, Leukemia

Pediatric CML: Life-Long Considerations With TKI Therapy
May 22, 2018, Cancer Therapy Advisor

Tasigna cleared for use in children with rare leukemia
March 23, 2018, PharmaTimes  

FDA Approves Nilotinib for Pediatric Chronic Myeloid Leukemia
March 22, 2018, Oncology Nursing News  

Dasatinib: A Safe and Effective Option for Pediatric CML
March 5, 2018, Cancer Therapy Advisor

Pediatric CML: Imatinib Effective in the Front Line
February 22, 2018, Cancer Therapy Advisor
 
Advanced Phases at Diagnosis of Childhood Chronic Myeloid Leukemia : The Experience of the International
Registry for Chronic Myeloid Leukemia (CML) in Children and Adolescents (I-CML-Ped Study)

December 2017, ASH 2017

Long-Term Outcome in Children and Adolescents with Chronic Myeloid Leukemia in Chronic Phase Treated with High-Dose Imatinib. the Italian Experience
December 2017, ASH 2017

Family, community rally around Bessemer girl battling leukemia
December 16 2016,  New Castle News

Childhood CML Survival Worst for Children Under 5 Years Old
October 19, 2016, Cancer Therapy Advisor

Disparities in Childhood CML Outcomes Persist Among Some European Countries and the US
October 11, 2016, Cancer Therapy Advisor

Pediatric chronic myeloid leukemia is a unique disease that requires a different approach
October 23, 2015, Journal Blood

Cord Blood Transplant: In Children, One Will Do
October 29, 2014, Medscape   

Waterloo girl  receives trip of a lifetime
November 21, 2013, hngnews.com

Imatinib cessation in children and  adolescents with chronic myeloid leukemia in chronic  phase
September 17, 2013, Pediatric Blood &  Cancer

Dasatinib Shows  Promise for Pediatric CML, ALL  Patients
September 13, 2013, Cancer  Network


Imatinib has adverse effect on growth in children with chronic myeloid leukemia.
September 2, 2012, deepdyve


Chronic myeloid leukemia in children and adolescents: Results of treatment with imatinib mesylate.
May 18, 2012, PubLmed

How I treat childhood CML
February 22, 2012, Journal Blood

Analysis of outcomes in adolescents and young adults with CML treated with upfront tyrosine kinase inhibitortherapy
January 22, 2012,Heamatologica
​
​
Analysis of risk factors influencing outcome in children with myelodysplastic syndrome after unrelated cord blood transplantation

March 25, 2011, PublMed

Controversies in the treatment of CML in children and adolescents: TKIs versus BMT?
January 17, 2011, Unbound Medline

Excellent outcomes of children with CML treated with imatinib mesylate compared to that in pre-imatinib era;
January 2011, International journal of hematology

Treatment of Pediatric Chronic Myeloid Leukemia in the Year 2010: Use of Tyrosine Kinase Inhibitors and Stem-Cell Transplantation
December 2010, Hematology

Acquired growth hormone deficiency in a girl with chronic myelogenous leukemia treated with tyrosine kinase inhibitor therapy.
December 22, 2010, Unbound Medline

Distinct Impact of Imatinib on Growth In Prepubertal and Pubertal Children with Chronic Myeloid Leukemia
December 5, 2010,  ASH2010

Dasatinib In Children and Adolescents with Relapsed or Refractory Leukemia: Results of the CA180018 Phase 1 Dose-Escalation Study of the Innovative Therapies for Children with Cancer (ITCC) Consortium
December 5, 2010,  ASH 2010  

Treatment of Pediatric Chronic Myeloid Leukemia in the Year 2010: Use of Tyrosine Kinase Inhibitors and Stem-Cell Transplantation
December 4, 2010,Hematology

Childhood Acute Myeloid Leukemia/Other Myeloid Malignancies Treatment
October 2010 (last modified), National Cancer Institute

Clinical characteristics and treatment outcome of pediatric patients with chronic myeloid leukemia
April 21, 2010, Haematologica

Impact of the type of the BCR-ABL fusion transcript on the molecular response in paediatric patients with chronic myeloid leukemia
February 2010, Haematologica

Outcome of 125 children with chronic myelogenous leukemia who received transplants from unrelated donors: the Japan Marrow Donor Program.
February 2010, PubLMed.com

Imatinib Is Efficient but Has a Negative Impact On Growth in Children with Previously Untreated chronic Myelogenous Leukaemia (CML) in Early Chronic Phase (CP): Results of the French National Phase IV Trial
December 2009, ASH 2009

Allogeneic stem cell transplantation for pediatric and adolescent patients with CML: results from the prospective trial CML-paed I
November 2009, PubMed

Growth deceleration in a girl treated with imatinib
January  20, 2009, The Japanese Society of Hematology

Molecular response of pediatric chronic myeloid leukemia (CML) with imatinib mesylate therapy
November 2008, Cancer Prevention research

Dasatinib in children and adolescents with relapsd or refractory leukemia preliminary results of the CA180018 PHASE I/II study from the ITCC CONSORTIUM
June  2008, 13th Congress of the European Hematology Association

Leucostase pulmonaire au cours d'une leucémie myéloïde chronique (in French)
2006, Santé tropicale.com


Clinical and Biological Features at Diagnosis in 40 Children With Chronic Myeloid Leukemia
July 2005 , Pediatrics

Treatment of CML in pediatric patients: should imatinib mesylate (STI-571, Gleevec) or allogeneic hematopoietic cell transplant be front-line therapy?
October 2004, PubLmed.gov

Early blastic transformation following complete cytogenetic response in a pediatric chronic myeloid leukemia patient treated with imatinib mesylate.
May 2004, PubLMed.gov

Build it and they will come (or will they?)
August 2003, Journal Blood

Stem cell transplantation for chronic myeloid leukemia in children
August 15, 2003, Journal Blood
               
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