Bosulif® (Bosutinib) - Chronic Myeloid Leukemia
Bosulif® (Bosutinib) is a third generation tyrosine kinase inhibitor. Unlike imatinib, bosutinib inhibits the autophosphorylation of both Abl and Src kinases, resulting in inhibition of cell growth and apoptosis (cell death). Responses were seen across Bcr-Abl mutations, including those associated with dasatinib and nilotinib resistance, except T315I.
Bosulif® (Bosutinib) is a third generation tyrosine kinase inhibitor. Unlike imatinib, bosutinib inhibits the autophosphorylation of both Abl and Src kinases, resulting in inhibition of cell growth and apoptosis (cell death). Responses were seen across Bcr-Abl mutations, including those associated with dasatinib and nilotinib resistance, except T315I.
CLINICAL TRIALS
Axitinib and Bosutinib for Patients With Chronic Myeloid Leukemia in Chronic, Accelerated or Blastic Phases
October 2018, ClinicalTrial.gov
Study of Efficacy of CML-CP Patients Treated With ABL001 Versus Bosutinib, Previously Treated With 2 or More TKIs
August 2017, ClinicalTrial.gov
Bosutinib in Elderly Chronic Myeloid Leukemia (BEST)
BCHILD - Bosutinib in Pediatric Patients [Denmark, France, Germany, Ireland, Israel, Italy, Netherlands, Spain, Switzerland, UK]
Axitinib and Bosutinib for Patients With Chronic Myeloid Leukemia in Chronic, Accelerated or Blastic Phases
October 2018, ClinicalTrial.gov
Study of Efficacy of CML-CP Patients Treated With ABL001 Versus Bosutinib, Previously Treated With 2 or More TKIs
August 2017, ClinicalTrial.gov
Bosutinib in Elderly Chronic Myeloid Leukemia (BEST)
BCHILD - Bosutinib in Pediatric Patients [Denmark, France, Germany, Ireland, Israel, Italy, Netherlands, Spain, Switzerland, UK]
VIDEOS
Bosutinib: a new, safer TKI for frontline CML (Dr. Michael Mauro)
August 15, 2018, VJHemOnc – Video Journal of Hematological Oncology
Jorge Cortes, MD, shares data presented at ASH 2017 regarding bosutinib in CML treatment
December 18, 2017, OBRoncology
Comparing Bosutinib Versus Imatinib in Newly Diagnosed CML (Dr. Jorge Cortes)
June 5, 2017, Targeted Oncology
What are the efficacy and safety considerations of bosutinib therapy? (Dr. Neil P. Shah)
April 29, 2016, MediCom Oncology
Bosutinib in the Second-Line Setting (Elias Jabbour, MD)
February 24, 2015, OncLiveTV
Dr. Shapiro Discusses Bosutinib in CML
December 23, 2013, OncLIve
Bosutinib as a treatment for newly diagnosed chronic myeloid leukaemia (Prof Carlo Gambacorti-Passerini )
February 18, 2011, ecancerTV
Bosutinib: a new, safer TKI for frontline CML (Dr. Michael Mauro)
August 15, 2018, VJHemOnc – Video Journal of Hematological Oncology
Jorge Cortes, MD, shares data presented at ASH 2017 regarding bosutinib in CML treatment
December 18, 2017, OBRoncology
Comparing Bosutinib Versus Imatinib in Newly Diagnosed CML (Dr. Jorge Cortes)
June 5, 2017, Targeted Oncology
What are the efficacy and safety considerations of bosutinib therapy? (Dr. Neil P. Shah)
April 29, 2016, MediCom Oncology
Bosutinib in the Second-Line Setting (Elias Jabbour, MD)
February 24, 2015, OncLiveTV
Dr. Shapiro Discusses Bosutinib in CML
December 23, 2013, OncLIve
Bosutinib as a treatment for newly diagnosed chronic myeloid leukaemia (Prof Carlo Gambacorti-Passerini )
February 18, 2011, ecancerTV
ARTICLES
Bosutinib Discontinuation Lowers Serum Creatinine in Chronic Myeloid Leukemia
February 27, 2025, Physician’s Weekly
Dose modification dynamics of ponatinib in patients with chronic-phase chronic myeloid leukemia (CP-CML) from the PACE and OPTIC trials
January 29, 2024, Leukemia
Impact of age and comorbidities on the efficacy and tolerability of bosutinib in previously treated patients with chronic myeloid leukemia: results from the phase 4 BYOND study
November 15, 2023, Leukemia
Asciminib May Improve HRQOL Vs Bosutinib in Resistant/Intolerant CML-CP
May 23, 2023, Cancer Network
High-grade B-cell lymphoma developed during the treatment of chronic myeloid leukemia with bosutinib
January 13, 2021, PubMed
Patients With Chronic-Phase CML Achieved Deeper, More Durable Molecular Responses With Asciminib Vs Bosutinib
December 13, 2021, CancerNetwork
Trial Data Highlight Safety and Efficacy of Bosutinib for Chronic-Phase CML
July 21, 2020, Oncology Learning Network
Pregnancy outcomes in patients treated with bosutinib
May 29, 2020, PubMed
Phase 2 study of bosutinib in Japanese patients with newly diagnosed chronic phase chronic myeloid leukemia
April 11, 2020, PubMed
Dose Optimization in Elderly CML Patients Treated with Bosutinib after Intolerance or Failure of First-Line Tyrosine Kinase Inhibitors
December 8, 2019, ASH 2019
Cross-Intolerance with Bosutinib after Prior Tyrosine Kinase Inhibitors in Patients with Chronic Phase Chronic Myeloid Leukemia: BYOND Phase 4 Study
December 8, 2019, ASH 2019
Bosutinib in the Real-Life Treatment of Chronic Phase Chronic Myeloid Leukemia (CML) Patients Aged > 65 Years Resistant/Intolerant to Frontline Tyrosine-Kynase Inhibitors
December 8, 2019, ASH 2019
Efficacy of Bosutinib in Imatinib-Resistant Vs Dasatinib/Nilotinib-Resistant Chronic Phase Chronic Myeloid Leukemia: Results from the Phase 4 BYOND Study
December 8, 2019, ASH 2019
Efficacy and Safety of Bosutinib By Charlson Comorbidity Index in Previously Treated Patients with Chronic Myeloid Leukemia: Results from the Phase 4 BYOND Study
December 8, 2019, ASH 2019
Effectiveness of Bosutinib in Chronic Myeloid Leukemia (CML) Who Have Received Multi Tyrosine Kinase Inhibitors (TKIs)
December 8, 2019, ASH 2019
Maintenance of Health-Related Quality of Life in the Phase 4 BYOND Study of Bosutinib for Pretreated Chronic Phase Chronic Myeloid Leukemia
December 8, 2019, ASH 2019
Phase 2 Study of Bosutinib in Japanese Patients with Newly Diagnosed Chronic Phase Chronic Myeloid Leukemia
December 8, 2019, ASH 2019
Incidence and evaluation of predisposition to cardiovascular toxicity in chronic myeloid leukemia patients treated with bosutinib in the real-life practice
May 1, 2019, PubMed
Bosutinib: Management of Adverse Events in Chronic Myeloid Leukemia
January 23, 2019, Cancer Therapy Advisor
Bosutinib Protects Against Endothelial Vascular Leakage by Preventing Focal Adhesion Disassembly
2018, ATS Journals
Management of adverse events associated with bosutinib treatment of chronic-phase chronic myeloid leukemia: expert panel review
December 27, 2018, NCBI
Real Life Evaluation of Efficacy and Safety of Bosutinib Therapy in Chronic Myeloid Leukemia Patients
December 2, 2018, ASH 2018
Correlation of plasma concentration and adverse effects of bosutinib: standard dose or dose-escalation regimens of bosutinib treatment for patients with chronic myeloid leukemia
April 13, 2018, PubMed
Bosutinib in chronic myeloid leukemia: patient selection and perspectives
April 9, 2018, Dove Medical Press
Bosutinib Nears EU Approval for Frontline Ph+ CML
February 26, 2018, OncLive
Practical management of toxicities associated with bosutinib in patients with Philadelphia chromosome-positive chronic myeloid leukemia
January 27, 2018, Annals of Oncology
FDA Approves Bosutinib for Newly-Diagnosed Ph+ CML
December 19, 2017, OncLive
Bosutinib in Newly Diagnosed Chronic Myeloid Leukemia (CML): Gastrointestinal (GI), Liver, and Hematological Safety Characterization in the BFORE Trial
December 2017, ASH 2017
Second-Line Bosutinib in Patients with Chronic Phase Chronic Myeloid Leukemia (CP CML) Resistant or Intolerant to Prior Imatinib: An 8-Year Update
December 2017, ASH 2017
Long-Term Cardiac, Vascular and Hypertensive Safety of Bosutinib in Patients with Philadelphia Chromosome-Positive (Ph+) Leukemia Resistant or Intolerant to Prior Therapy
December 2017, ASH 2017
Optimizing Dose of Bosutinib to Minimize Adverse Events While Maintaining Efficacy in Patients with Newly Diagnosed Chronic Myelogenous Leukemia
December 2017, ASH 2017
Bosutinib Safe, Effective in Second and Third Line Among Patients With CML
October 27, 2017, Cancer Therapy Advisor
Trial Compares Bosutinib and Imatinib for First-Line CML Rx
September 21, 2017, Clinical Oncology News
Bosutinib Distinguishes Itself as Potential Option for Newly-Diagnosed CML
September 15, 2017, Targeted Oncology
Frontline bosutinib 'an option' for newly diagnosed CP CML
June 22, 2017, MedwireNews
Bosutinib vs Imatinib for First-line Chronic Myeloid Leukemia Treatment
June 7, 2017, Cancer Therapy Advisor
Effects of Bosutinib Treatment on Renal Function in Patients With Philadelphia Chromosome-Positive Leukemias **** WARNING ***
June 2017, Clinical Lymphoma, Myeloma and leukemia
Long-term treatment with bosutinib in a phase 1/2 study in Japanese chronic myeloid leukemia patients resistant/intolerant to prior tyrosine kinase inhibitor treatment
April 13, 2017, PubMed
Frontline Bosutinib Superior to Imatinib for Philadelphia Chromosome-Positive Chronic Myeloid Leukemia in Chronic Phase
February 9, 2017, OncolyNurseAdvisor
Efficacy and Safety Following Bosutinib Dose Reduction in Patients with Philadelphia Chromosome‒Positive Chronic Myeloid Leukemia
December 2016, ASH 2016
Immunological Monitoring of CML Patients during First-Line Bosutinib and Imatinib Treatment
December 2016, ASH 2016
Bosutinib Offers Long-Term Efficacy in CML Patients Who Failed TKI Therapy
November 23, 2016, Cancer Network
Bosutinib for CML After Progression With First-line TKI
November 10, 2016, Cancer Therapy Advisor
Long-term later-line bosutinib benefits CML patients
October 18, 2016, medwireNews
Deterioration of pulmonary hypertension and pleural effusion with bosutinib following dasatinib lung toxicity
August 25, 2016, European Respiratory Journal
Bosutinib shows 'low' vascular, cardiac event risk profile
April 21, 2016, News-Medical.net
Long-term evaluation of cardiac and vascular toxicity in patients with Philadelphia chromosome-positive leukemias treated with bosutinib
April 12,2016, Europe PMC
Positive bosutinib response for elderly blast phase CML patient
January 22, 2016, News-Medical.net
Predictors of Response Duration and Survival with Second-Line Bosutinib Therapy in Patients (pts) with Chronic Phase Chronic Myeloid Leukemia (CML) Resistant or Intolerant to Prior Imatinib
December 7, 2015, ASH 2015
Safety and Efficacy of Bosutinib in Fourth Line Therapy of Chronic Myeloid Leukemia Patients
December 6, 2015, ASH 2015
Study Assesses Factors Influencing Bosutinib Efficacy, Safety in CML
November 5, 2015, Oncology Nurse Advisor
Bosutinib is well-suited for older patients with chronic myeloid leukemia
July 3, 2015, Medical News Today
Long-term Bosutinib in patients with chronic phase CML after prior imatinib failure
June 2015, EHA 2015
Long-term evaluation of vascular toxicity in patients with Ph+ leukemias treated with bosutinib
June 2, 2014, PubMed
Bosutinib safety and management of toxicity in leukemia patients with resistance or intolerance to imatinib and other tyrosine kinase inhibitors
December 17, 2013, Journal Blood
Pfizer’s Bosutinib Receives Positive Opinion For Conditional Marketing Authorization From The Committee For Medicinal Products For Human Use For The Treatment Of Ph+ Chronic Myelogenous Leukemia With Resistance Or Intolerance To Prior Therapy In Europe
January 18, 2013, Pfizer
Pfizer's Bosulif set for greater sales with EMA approval
January 18, 2013, Fierce Pharna
Pfizer, Novartis win EU nods for new leukemia, eye drugs
January 18, 2013, FierceBiotech
Bosutinib a New Option for Chronic Myeloid Leukemia
December 2012, Clinical Oncology
FDA approves orphan drug for CML
October 1, 2012, HemOnc Today
FDA Approves Bosutinib (Bosulif) for Chronic Myeloid Leukemia (CML)
September 5, 2012, Cancer Network
Bosutinib Versus Imatinib in Newly Diagnosed Chronic-Phase Chronic Myeloid Leukemia: Results From the BELA Trial
September 4, 2012, PubMed
Bosutinib Achieves Faster Response Rates in Newly Diagnosed Chronic Phase CML Patients Than Imatinib
June 3 , 2011, Monthly Prescribing Reference
STUDY 200: Study Evaluating Bosutinib in Philadelphia Chromosome Positive Leukemia
June 3, 2011, Pfizer Oncology
Pfizer Plans Regulatory Submissions Of Bosutinib In Chronic Myeloid Leukemia
December 3, 2010, Pfizer Oncology
Bosutinib Discontinuation Lowers Serum Creatinine in Chronic Myeloid Leukemia
February 27, 2025, Physician’s Weekly
Dose modification dynamics of ponatinib in patients with chronic-phase chronic myeloid leukemia (CP-CML) from the PACE and OPTIC trials
January 29, 2024, Leukemia
Impact of age and comorbidities on the efficacy and tolerability of bosutinib in previously treated patients with chronic myeloid leukemia: results from the phase 4 BYOND study
November 15, 2023, Leukemia
Asciminib May Improve HRQOL Vs Bosutinib in Resistant/Intolerant CML-CP
May 23, 2023, Cancer Network
High-grade B-cell lymphoma developed during the treatment of chronic myeloid leukemia with bosutinib
January 13, 2021, PubMed
Patients With Chronic-Phase CML Achieved Deeper, More Durable Molecular Responses With Asciminib Vs Bosutinib
December 13, 2021, CancerNetwork
Trial Data Highlight Safety and Efficacy of Bosutinib for Chronic-Phase CML
July 21, 2020, Oncology Learning Network
Pregnancy outcomes in patients treated with bosutinib
May 29, 2020, PubMed
Phase 2 study of bosutinib in Japanese patients with newly diagnosed chronic phase chronic myeloid leukemia
April 11, 2020, PubMed
Dose Optimization in Elderly CML Patients Treated with Bosutinib after Intolerance or Failure of First-Line Tyrosine Kinase Inhibitors
December 8, 2019, ASH 2019
Cross-Intolerance with Bosutinib after Prior Tyrosine Kinase Inhibitors in Patients with Chronic Phase Chronic Myeloid Leukemia: BYOND Phase 4 Study
December 8, 2019, ASH 2019
Bosutinib in the Real-Life Treatment of Chronic Phase Chronic Myeloid Leukemia (CML) Patients Aged > 65 Years Resistant/Intolerant to Frontline Tyrosine-Kynase Inhibitors
December 8, 2019, ASH 2019
Efficacy of Bosutinib in Imatinib-Resistant Vs Dasatinib/Nilotinib-Resistant Chronic Phase Chronic Myeloid Leukemia: Results from the Phase 4 BYOND Study
December 8, 2019, ASH 2019
Efficacy and Safety of Bosutinib By Charlson Comorbidity Index in Previously Treated Patients with Chronic Myeloid Leukemia: Results from the Phase 4 BYOND Study
December 8, 2019, ASH 2019
Effectiveness of Bosutinib in Chronic Myeloid Leukemia (CML) Who Have Received Multi Tyrosine Kinase Inhibitors (TKIs)
December 8, 2019, ASH 2019
Maintenance of Health-Related Quality of Life in the Phase 4 BYOND Study of Bosutinib for Pretreated Chronic Phase Chronic Myeloid Leukemia
December 8, 2019, ASH 2019
Phase 2 Study of Bosutinib in Japanese Patients with Newly Diagnosed Chronic Phase Chronic Myeloid Leukemia
December 8, 2019, ASH 2019
Incidence and evaluation of predisposition to cardiovascular toxicity in chronic myeloid leukemia patients treated with bosutinib in the real-life practice
May 1, 2019, PubMed
Bosutinib: Management of Adverse Events in Chronic Myeloid Leukemia
January 23, 2019, Cancer Therapy Advisor
Bosutinib Protects Against Endothelial Vascular Leakage by Preventing Focal Adhesion Disassembly
2018, ATS Journals
Management of adverse events associated with bosutinib treatment of chronic-phase chronic myeloid leukemia: expert panel review
December 27, 2018, NCBI
Real Life Evaluation of Efficacy and Safety of Bosutinib Therapy in Chronic Myeloid Leukemia Patients
December 2, 2018, ASH 2018
Correlation of plasma concentration and adverse effects of bosutinib: standard dose or dose-escalation regimens of bosutinib treatment for patients with chronic myeloid leukemia
April 13, 2018, PubMed
Bosutinib in chronic myeloid leukemia: patient selection and perspectives
April 9, 2018, Dove Medical Press
Bosutinib Nears EU Approval for Frontline Ph+ CML
February 26, 2018, OncLive
Practical management of toxicities associated with bosutinib in patients with Philadelphia chromosome-positive chronic myeloid leukemia
January 27, 2018, Annals of Oncology
FDA Approves Bosutinib for Newly-Diagnosed Ph+ CML
December 19, 2017, OncLive
Bosutinib in Newly Diagnosed Chronic Myeloid Leukemia (CML): Gastrointestinal (GI), Liver, and Hematological Safety Characterization in the BFORE Trial
December 2017, ASH 2017
Second-Line Bosutinib in Patients with Chronic Phase Chronic Myeloid Leukemia (CP CML) Resistant or Intolerant to Prior Imatinib: An 8-Year Update
December 2017, ASH 2017
Long-Term Cardiac, Vascular and Hypertensive Safety of Bosutinib in Patients with Philadelphia Chromosome-Positive (Ph+) Leukemia Resistant or Intolerant to Prior Therapy
December 2017, ASH 2017
Optimizing Dose of Bosutinib to Minimize Adverse Events While Maintaining Efficacy in Patients with Newly Diagnosed Chronic Myelogenous Leukemia
December 2017, ASH 2017
Bosutinib Safe, Effective in Second and Third Line Among Patients With CML
October 27, 2017, Cancer Therapy Advisor
Trial Compares Bosutinib and Imatinib for First-Line CML Rx
September 21, 2017, Clinical Oncology News
Bosutinib Distinguishes Itself as Potential Option for Newly-Diagnosed CML
September 15, 2017, Targeted Oncology
Frontline bosutinib 'an option' for newly diagnosed CP CML
June 22, 2017, MedwireNews
Bosutinib vs Imatinib for First-line Chronic Myeloid Leukemia Treatment
June 7, 2017, Cancer Therapy Advisor
Effects of Bosutinib Treatment on Renal Function in Patients With Philadelphia Chromosome-Positive Leukemias **** WARNING ***
June 2017, Clinical Lymphoma, Myeloma and leukemia
Long-term treatment with bosutinib in a phase 1/2 study in Japanese chronic myeloid leukemia patients resistant/intolerant to prior tyrosine kinase inhibitor treatment
April 13, 2017, PubMed
Frontline Bosutinib Superior to Imatinib for Philadelphia Chromosome-Positive Chronic Myeloid Leukemia in Chronic Phase
February 9, 2017, OncolyNurseAdvisor
Efficacy and Safety Following Bosutinib Dose Reduction in Patients with Philadelphia Chromosome‒Positive Chronic Myeloid Leukemia
December 2016, ASH 2016
Immunological Monitoring of CML Patients during First-Line Bosutinib and Imatinib Treatment
December 2016, ASH 2016
Bosutinib Offers Long-Term Efficacy in CML Patients Who Failed TKI Therapy
November 23, 2016, Cancer Network
Bosutinib for CML After Progression With First-line TKI
November 10, 2016, Cancer Therapy Advisor
Long-term later-line bosutinib benefits CML patients
October 18, 2016, medwireNews
Deterioration of pulmonary hypertension and pleural effusion with bosutinib following dasatinib lung toxicity
August 25, 2016, European Respiratory Journal
Bosutinib shows 'low' vascular, cardiac event risk profile
April 21, 2016, News-Medical.net
Long-term evaluation of cardiac and vascular toxicity in patients with Philadelphia chromosome-positive leukemias treated with bosutinib
April 12,2016, Europe PMC
Positive bosutinib response for elderly blast phase CML patient
January 22, 2016, News-Medical.net
Predictors of Response Duration and Survival with Second-Line Bosutinib Therapy in Patients (pts) with Chronic Phase Chronic Myeloid Leukemia (CML) Resistant or Intolerant to Prior Imatinib
December 7, 2015, ASH 2015
Safety and Efficacy of Bosutinib in Fourth Line Therapy of Chronic Myeloid Leukemia Patients
December 6, 2015, ASH 2015
Study Assesses Factors Influencing Bosutinib Efficacy, Safety in CML
November 5, 2015, Oncology Nurse Advisor
Bosutinib is well-suited for older patients with chronic myeloid leukemia
July 3, 2015, Medical News Today
Long-term Bosutinib in patients with chronic phase CML after prior imatinib failure
June 2015, EHA 2015
Long-term evaluation of vascular toxicity in patients with Ph+ leukemias treated with bosutinib
June 2, 2014, PubMed
Bosutinib safety and management of toxicity in leukemia patients with resistance or intolerance to imatinib and other tyrosine kinase inhibitors
December 17, 2013, Journal Blood
Pfizer’s Bosutinib Receives Positive Opinion For Conditional Marketing Authorization From The Committee For Medicinal Products For Human Use For The Treatment Of Ph+ Chronic Myelogenous Leukemia With Resistance Or Intolerance To Prior Therapy In Europe
January 18, 2013, Pfizer
Pfizer's Bosulif set for greater sales with EMA approval
January 18, 2013, Fierce Pharna
Pfizer, Novartis win EU nods for new leukemia, eye drugs
January 18, 2013, FierceBiotech
Bosutinib a New Option for Chronic Myeloid Leukemia
December 2012, Clinical Oncology
FDA approves orphan drug for CML
October 1, 2012, HemOnc Today
FDA Approves Bosutinib (Bosulif) for Chronic Myeloid Leukemia (CML)
September 5, 2012, Cancer Network
Bosutinib Versus Imatinib in Newly Diagnosed Chronic-Phase Chronic Myeloid Leukemia: Results From the BELA Trial
September 4, 2012, PubMed
Bosutinib Achieves Faster Response Rates in Newly Diagnosed Chronic Phase CML Patients Than Imatinib
June 3 , 2011, Monthly Prescribing Reference
STUDY 200: Study Evaluating Bosutinib in Philadelphia Chromosome Positive Leukemia
June 3, 2011, Pfizer Oncology
Pfizer Plans Regulatory Submissions Of Bosutinib In Chronic Myeloid Leukemia
December 3, 2010, Pfizer Oncology
