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Chronic Myeloid Leukemia

Cure possible for Chronic Myeloid Leukemia (CML) ?
                       

Combination of ruxolitinib with tyrosine kinase inhibitor

Important notice: You must inform your CML doctor or a qualified doctor before using this drug. The material presented here is for information purposes only;  it is not a substitute for your physician’s guidance and care.

Ruxolitinib (Jakavi) is a JAK1/JAK2 inhibitor and is used in myelofibrosis and MPNs. Scientists have found that ruxolitinib in combination with tyrosine kinase inhibitors can potentially kill CML stem cells through the STAT5 pathway.
            

VIDEOS

Dr. Mesa on the Mechanism of Action of Ruxolitinib in CML
March 13, 2013, Targeted Oncology
​
CLINICAL TRIALS

Ruxolitinib in Combination With Nilotinib in Chronic Myeloid Leukemia (CML) Patients
​
Ruxolitinib for Chronic Myeloid Leukemia (CML) With Minimal Residual Disease (MRD)

Phase I/II Study of Nilotinib/Ruxolitinb Therapy for TKI Resistant Ph-Leukemia

Safety and Tolerability of Combined Treatment With Nilotinib and Ruxolitinib in CML and Ph+ ALL Patients (CoRNea)

 
ARTICLES

Ruxolitinib/nilotinib cotreatment inhibits leukemia-propagating cells in Philadelphia chromosome-positive ALL
August 30, 2017, Journal of Translational Medicine

A Phase I Study of Ruxolitinib Plus Nilotinib in Chronic Phase CML Patients with Molecular Evidence of Disease

2016, Journal Blood
​
Concomitant JAK2 V617F-positive polycythemia vera and BCR-ABL-positive chronic myelogenous leukemia treated with ruxolitinib and dasatinib
October 2, 2015, Journal Blood  

JAK2/STAT5 inhibition by nilotinib with ruxolitinib contributes to the elimination of CML CD34+ cells in vitro and in vivo
2014, Journal Blood
​
Janus kinase inhibition by ruxolitinib extends dasatinib- and dexamethasone-induced remissions in a mouse model of Ph+ ALL
June 2014, Journal Blood

Imatinib and ruxolitinib association: first experience in two patients
June 2014, Haematologica


                                          See also Tasigna@ (Nilotinib)
                
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