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  • CML Experts
    • Team of experts on CML who developed imatinib >
      • Dr. Elisabeth Buchdunger
      • Dr. Brian Druker
      • Dr. John Goldman
      • Dr. Carlo Gambacorti-Passerini
      • Dr. Nora C. Heisterkamp
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      • Dr. Moshe Talpaz
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      • Dr. Charles Sawyers
      • Dr. Jürg Zimmermann
      • Dr. Owen Witte
    • Experts involved in developing dasatinib >
      • Dr. Jagabandhu Das
    • Experts involved in developing nilotinib
    • CML experts in America >
      • CML experts in Canada >
        • How to get the CMLer's password?
        • Dr. Sarit Assouline
        • Dr. Lambert Busque
        • Dr. Robert Delage
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        • Dr. Josée Hébert
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      • CML experts in US >
        • How to get the CMLer's password?
        • Carolyn Blasdel, RN , FNP-BC, OCN
        • Rey Garcia, RN, BSN
        • PATRICIA JAKEL, RN, MN, AOCN
        • Dr. Charles Schiffer
        • Dr. B. Douglas Smith
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        • Dr. Sangmin Lee
        • Dr. Srinivas K. Tantravahi
        • Dr. Bin Zhang
      • CML experts in South America >
        • Dr. Michele Bianchini
        • Dra Beatriz Moiraghi
        • Dra. Carla Boquimpani
        • Dr Carolina Pavlovsky
    • CML Experts in Europe >
      • CML Expert in Belgium >
        • Pr Gregor Verhoef
      • CML expert in France >
        • Comment obtenir le mot de passe?
        • Dr. François-Xavier Mahon
        • Dr Aude Charbonnier
        • Dr. Agnès Guerci Bresler
        • Dr Pascale Cony-Makhoul
        • Dr. Delphine Rea
        • Dr. Gabriel Etienne
        • Dr. Lawrence Legros
        • Dr. Marie-Joëlle Mozziconacci
        • Pr. Mauricette Michallet
        • Dr. François Guilhot
        • Dr. ​Emilie Cayssial
        • Dr Françoise Huguet
        • Dr. Stéphane Prost
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        • Dr. Eliane Gluckman
        • Dr. Franck-Emmanuel Nicolini
      • CML expert in Italy >
        • Dr. Carlo Gambacorti-Passerini
        • Dr. Chiara Elena
        • Dr. Gianantonio Rosti
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        • Dr. Michele Baccarani
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      • CML expert in UK >
        • Dr. Jane Apperley
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        • Dr. Adam Mead
        • Dr. Tessa L Holyoake
      • CML expert in Germany >
        • Dr. Andreas Hochhaus
        • Professor Jörg Hasford
        • Professor Oliver Hantschel​
        • Dr Susanne Saussele
        • Dr. Martin Müller
      • CML expert in Portugal >
        • Dr. Antônio Medina de Almeida
      • CML expert in Spain >
        • Dr. Juan Luis Steegmann
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        • Dr. Jeroen J.W.M. Janssen
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        • Dr. Johan Richter
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        • Dr. Hana Klamova
    • CML experts in Asia >
      • Dr. Annuar Rapaee
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    • CML experts in Africa >
      • Dr. Asmaa Quessar
      • Dr. Anthony Oyekunle
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      • Dr. Ilaria Pagani
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      • Dr. Anthony P Schwarer
  • Medical Concepts
    • Introduction to CML >
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    • General concepts >
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        • Polymerase Chain Reaction (PCR)
        • Dr. Kary Bank Mullis
      • Non-adherence of CML patients
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  • Medication
    • How to get the CMLer's password?
    • Hydroxyurea
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      • Generic nilotinib
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      • Generic Dasatinib
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    • (Bafetinib)
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    • BP1001
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  • Managing side effects
    • List of side effets >
      • How to get the CMLer's password?
      • Acid Uric - Gout
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    • Psycho-Oncology
    • Complementary and Alternative Medicine >
      • Art Therapy >
        • Art Therapist
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        • YouTube creation by CMLer's family
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        • Debussy – Relaxing music - Clair de lune et autres...
        • Delicate music for the soul and LIFE, and birdsong soothes the nervous system.
        • Adagio for Strings (Samuel Barber)
        • Amélie Soundtrack ♥ Comptine d'Un Autre Été
        • The song "Disenchanted'
      • Yoga
      • Physical Activity
      • Zootherapy
  • Patient Testimonials
    • 30 years and plus survivors >
      • How to get the CMLer's password?
      • Mark Popadick
      • Mary Sullivan
      • Dr. Robert Patenaude -E
      • Skip Duffe
      • Sister Shirley Vaughn
    • 20 years and plus survivors >
      • How to get the CMLer's password?
      • Doug Jenson
      • Giora Sharf
      • Joannie Clements
      • Mel Mann
      • Kevin Williams
      • Rich Jones
      • Tanja Fajon
      • Tamera Simonson
      • Virginia Garner
    • 10 years and plus survivors >
      • How to get the CMLer's password?
      • Dan Sloan
      • Drew Johnston
      • Erin Zammett Ruddy
      • Erin Havel (Author)
      • Gary Gonzales
      • Jan Geissler
      • Jean McGlynn
      • Jo'story
      • Kayla Naton (Pregnancy)
      • Leanne
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      • Pat Elliott
      • Rob Shick
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      • Tom Cleaver
      • Sohag
    • New CMLers >
      • How to get the CMLer's password?
      • Skye Davidson
      • Amanda Steffy
      • Abbi Evans
      • Alyssa
      • Austin Granatowicz
      • Brown Dudley
      • Nigel
      • Katie
      • Kris
      • Ron Robbecke
    • Celebrities with CML >
      • How to get the CMLer's password?
      • Alexa Score
      • Brian Boyle
      • Carlos Carrasco
      • Charlie Schlatter
      • Doris Muramatsu
      • Dr. Richard Rockefeller
      • Greg Lemond
      • Kareem Abdul-Jabar
      • Kelvin Alston
      • Jason Blake
      • Laura Boyd
      • Lee Zeldin
      • Rick Upchurch
      • Roman Reigns
      • Ryan O'Neal
      • Tim Holcomb
    • Suzan Mc Namara and the petition
    • Bud Romine - the first patient
    • Other testimonials
    • Blogs >
      • How to get the password?
      • Living with CML
      • Michelle D's Blog
      • Jon's Blog
      • Trey's Blog
      • Blogs not recently updated >
        • Access CML Drugs
        • CMKID's blog – Dislodging the bullet - 2012
        • CML Recovery - Stopping KTI -2011
        • Hans's Blog -2012
        • Elizabeth's Blog - my leukemia - 2013journey
        • Elizabeth's Blog - Heart of the rose -2011
        • Joe's Blog - 2012
        • Josh's Blog - 2014
        • Mannan's Blog -2014
        • Ian's Blog -2014
        • Matt's Blog - 2012
        • Matthew's Blog - 2014
        • Michelle's Blog -2012
        • Nayree's Blog -2011
        • Rob's Blog - 2011
  • Global News on CML
    • English - Latest CML News >
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  • Various topics
    • How to get the CMLer's password?
    • CML patients and the coronavirus
    • You’ve just been diagnosed
    • History of CML
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    • Pronostic, life expectancy, quality of life, ..... in chronic myeloid leukemia
    • Increased Risk of Secondary Cancers with CML
    • Vaccination of CMLers
    • CML Blast Crisis treatment
    • Bone marrow transplant
    • Stem cells from umbilical cord blood
    • Children with CML
    • CML and pregnancy
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    • Elderly patients with CML
    • Sports with CML
    • CML Awareness Day >
      • Journée mondiale de sensibilisation à la leucémie myéloïde chronique
    • The movie "Dying to Survive"
    • The movie 'The Blue Butterfly"
  • Cure possible for CML?
    • How to get the CMLer's password?
    • Hematopoietic stem cell transplantation using single UM171-expanded cord blood >
      • Greffe de cellules souches de cordon ombilical amplifiées par la molécule UM171
    • Combination of tyrosine kinase inhibitor with other medication >
      • Combinaison of hydroxychloroquine with tyrosine kinase inhibitor
      • Combination of ruxolitinib with tyrosine kinase inhibitor
      • Combination of miristen with tyrosine kinase inhibitor
      • Combination of pioglitazone with tyrosine kinase inhibitor
      • Combination of Inecalcitol with tyrosine kinase inhibitor
      • Combination of dasatinib plus Nivolumab
      • Combination of Pembrolizumab with tyrosine kinase inhibitor
      • Combination of interferon with tyrosine kinase inhibitor
      • Combination of Venetoclax with tyrosine kinase inhibitor
    • Inhibitory effect of c-Myc on p53-induced apoptosis in leukemia cells
    • Inhibition of the protein Ezh2 can cure CML?
    • Inhibition of STAT5 in conjunction with standard TKI therapy
    • PROTAC-mediated Targeted Protein Degradation
    • CML vaccine
    • Can immunotherapy cure leukemia?
    • Could fasting cure chronic myeloid leukemia
    • Chimeric Antigen Receptor T-Cell Therapy
    • Can genetic sequencing help to cure leukemia?
    • Can the new drug CX-5461 cure leukemia?
    • CRISPR-Cas9 gene-editing technique
    • Presence of bcr abl fusion transcripts in healthy individua
    • Math could help cure leukemia
    • Natural Medicine >
      • Possible cure for CML in Fish Oil
      • Betel leaf may help fight CML
      • Feverfew extract (parthenolide)
      • Can dandelions kill cancer?
      • Can curcumin cure leukemia?
  • Treatment free remission(TFR)
    • The French trial called STIM (Stop Imatinib)
    • De-escalation of treatment
    • Tyrosine Kinase Inhibitor Withdrawal Syndrome in CML Patients
  • Educational videos (all languages)
    • Educational videos in English >
      • Educational videos (in English)
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      • Educación de vídeos en español (in Spanish)
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    • Be happy
  • Congresses, conferences, meetings ASH, ASCO, EHA ...
    • ASCO - American Society of Clinical Oncology >
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      • BTG2019 - Fuzhou - China
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Chronic Myeloid Leukemia

History of CML  - Chronic Myeloid Leukemia

Picture
              In 1845, CML was first described by two pathologists, Dr. Rudolf Virchow (Berlin,Germany) and Dr. John Hughes Bennett (Edinburgh, Scotland)  . In 1865, Heinrich Lissauer described the use of arsenic in patients with leukemia. 
               In 1959, two scientists at the University of Pennsylvania (Dr. Peter C. Nowell and Dr. David E. Hungerford) noticed that the chromosome 22 in the blood cells of many CML patients was shorter than normal. After this chromosome was nicknamed "the Philadelphia chromosome".
               In 1973, Dr. Janet Rowley determined that the shortened chromosome 22, the so-called Philadelphia (Ph) chromosome, was the product of a reciprocal translocation between the long arms of chromosomes 9 and 22.

                  In the mid-1970s, a Seattle group reported the disappearance of the Ph chromosome in CML patients who underwent allotransplant. CML can be cured for the first time. Also, interferon-α was found to induce durable complete cytogenetic responses and long-term survival, although in only a small fraction of patients.
                  By the 1980s, Owen Witte, M.D., and his colleagues at the University of California, Los Angeles,  were able to use genetic mapping to show that the two ends of the broken chromosomes produced a cancer-causing protein, known as Bcr-Abl.
                   In 1998, the tyrosine kinase inhibitors (TKI) was introduced. Clinical trials was initiated by Dr. Brian Druker.  The first patient took the first dose of STI-571 (now Gleevec) in  June 25, 1998 at Oregon Health Sciences University. In 2001, Gleevec (imatinib) was appoved by the Food and Drug Administration (FDA)
​​
VIDEOS

Clinical trial saves leukemia patient from death (History of STI-571 1999 )  
April 14, 2016, Virginia Garner
​

Leukemia Patient Tells of New Drug (History of STI-571 1999 )  
April 12, 2016, Virginia Garner

2012 (28th) Japan Prize: Dr. Rowley / Dr. Druker / Dr. Lydon 
     
April 24, 2012,  JapanPrize
​
The End of Cancer is within reach                                          
 2009, Knight Cancer institute, OHSU

​The first day of clinical trials for Gleevec, Bud and Yvonne by DNA Learning Center 
​‘’The first patient, 68-year-old Bud Romine from Tillamook, Ore., will take his first dose of the experimental drug (on Thursday, June 25, 1998, at Oregon Health Sciences University’’ 


​Nixon Signing the National Cancer Act of 1971                                                       
August 11, 2016, Succesboeken
ARTICLES

How Imatinib Transformed Leukemia Treatment and Cancer Research
April 11, 2018, National Cancer Institute


The survivors: How an experimental treatment saved patients and changed medicine
April 25, 2017, Stat News

Chronic myeloid leukemia: reminiscences and dreams
2016, Haematologica


A Critical History of Chronic Myeloid Leukemia
January 2, 2014, Europe PMC

A Triumph in the War Against Cancer
May 2011, Smithsonian magazine


Chronic Myeloid Leukemia: A Historical Perspective (by Dr. John Goldman)
October 2010, Science Direct


50th Anniversary of the Discovery of the Philadelphia Chromosome
September 28, 2010, Fox Chase Cancer Center


Executive Summary of a Book: Magic  Cancer Bullet
May 23, 2009, Discovery Medecine


Translation of the Philadelphia chromosome into therapy for  CML
December 15, 2008, Journal  Blood


The history of myeloproliferative disorders: before and after Dameshek
2008, Leukemia


Chronic Myeloid Leukemia: An Historical Perspective
January 1, 2008, ASH Publications


The History Of  Glivec
December 27, 2005, Medical News Today


THE BCR-ABL STORY: Bench to Bedside and Back
April 23, 2004, Annual reviews
 
Thriving with chronic myeloid leukaemia
December 1, 2001, The Lancet


Powerful Anti-Cancer Drug Emerges from Basic Biology
May 2001, New-York Times


OHSU Scientists Begin Human Trials Of A Drug Aimed At The Underlying Cause Of Chronic Myelogenous Leukemia
June 25,1998, EurekAlert



​Suzan Mc Namara is the patient  who started a petition to Novartis which is a corporation that produced pills for clinical trials conducted by Dr. Druker for CML patients
LITERATURE
​

The Philadelphia Chromosome by Jessica  Wapner
February 15, 2013, CMLeukemia.com

Other books
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