Possible cure for CML in Fish Oil Chronic Myeloid Leukemia
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The compound Δ12-prostaglandin J3, an omega-3 fatty acid–derived metabolite, selectively ablates CML stem cells in mice. This compound is produced from EPA, Eicosapentaenoic Acid, an Omega-3 fatty acid found in fish and in fish oil. The compound Δ12-PGJ3 selectively targeted leukemia stem cells (LSCs) for apoptosis in the spleen and BM.
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Important notice: You must inform your CML doctor or a qualified doctor if you want to take Fish Oil or other product. The material presented here is for information purposes only; it is not a substitute for your physician’s guidance and care. Fish oil—long encouraged by doctors as a supplement to support heart and joint health—induces severe colitis and colon cancer in mice in new research
VIDEOS
Penn State: Inspiring Collaboration
February 2, 2012, Penn State
Fish Oil Derivative Cures Cancer
December 30, 2011, Doctor Saputo
Penn State: Inspiring Collaboration
February 2, 2012, Penn State
Fish Oil Derivative Cures Cancer
December 30, 2011, Doctor Saputo
CLINICAL TRIALS
Omega -3 Fatty Acid in Combination With Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia
August 21, 2019, ClinicalTrials.org
Omega-3 Fatty Acids in Treating Patients With Advanced Cancer Who Have Significant Weight Loss
July 13,, 2019, ClinicalTrials.org
Omega -3 Fatty Acid in Combination With Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia
August 21, 2019, ClinicalTrials.org
Omega-3 Fatty Acids in Treating Patients With Advanced Cancer Who Have Significant Weight Loss
July 13,, 2019, ClinicalTrials.org
ARTICLES
Could Fish Oil Interfere With Chemotherapy?
April 2, 2015, WebMD
Fish tied to lower colon cancer risk: study
May 10, 2012, Chicago Tribune
Potential Role of Fish Oil to Cure Leukemia
January 1, 2012, HIVE Health Media
Fish oil may help cure leukemia
December 24, 2011, The Hindu
''During the experiments, the researchers injected each mouse with about 600 nanograms of D12—PGJ3 each day for a week. Tests showed that the mice were completely cured of the disease. The blood count was normal, and the spleen returned to normal size. The disease did not relapse.''
Penn State University researchers take steps toward finding a cure for leukemia
December 22, 2011, Pennlive.com
Fish oil may hold key to leukemia cure
December 22, 2011, MedicalXpress
The antileukemic activity of Δ12-PGJ3
December 22, 2011, Journal Blood
''The salutory effects of fish oil ω-3 polyunsaturated fatty acids (n-3 PUFAs) include reduced inflammatory and cardiovascular disease and prevention of cancer.2,3 Apart from the role of n-3 PUFAs in disease prevention, recent studies suggest that n-3 PUFA metabolites may have a place in cancer treatment...''
Δ12-prostaglandin J3, an omega-3 fatty acid–derived metabolite, selectively ablates leukemia stem cells in mice December 22, 2011, Journal Blood
''Δ12-prostaglandin J3, an omega-3 fatty acid–derived metabolite, selectively ablates leukemia stem cells in mice….IP administration of Δ12-PGJ3 to mice infected with Friend erythroleukemia virus or those expressing the chronic myelogenous leukemia oncoprotein BCR-ABL in the hematopoietic stem cell pool completely restored normal hematologic parameters, splenic histology, and enhanced survival. More importantly, Δ12-PGJ3 selectively targeted leukemia stem cells (LSCs) for apoptosis in the spleen and BM. This treatment completely eradicated LSCs in vivo, as demonstrated by the inability of donor cells from treated mice to cause leukemia in secondary transplantations….''
Possible Cure for Leukemia Found in Fish Oil
December 22, 2011, Science Daily
Fish oil may hold key to leukemia cure
December 22, 2011, Eurek Alert
Fish Oil Reduces Effectiveness of Chemotherapy WARNING
September 12, 2011, Science Daily
How much fish oil is too much? IMPORTANT NOTICE
October 6, 2010, Futurity
Fish oil—long encouraged by doctors as a supplement to support heart and joint health—induces severe colitis and colon cancer in mice in new research
Could Fish Oil Interfere With Chemotherapy?
April 2, 2015, WebMD
Fish tied to lower colon cancer risk: study
May 10, 2012, Chicago Tribune
Potential Role of Fish Oil to Cure Leukemia
January 1, 2012, HIVE Health Media
Fish oil may help cure leukemia
December 24, 2011, The Hindu
''During the experiments, the researchers injected each mouse with about 600 nanograms of D12—PGJ3 each day for a week. Tests showed that the mice were completely cured of the disease. The blood count was normal, and the spleen returned to normal size. The disease did not relapse.''
Penn State University researchers take steps toward finding a cure for leukemia
December 22, 2011, Pennlive.com
Fish oil may hold key to leukemia cure
December 22, 2011, MedicalXpress
The antileukemic activity of Δ12-PGJ3
December 22, 2011, Journal Blood
''The salutory effects of fish oil ω-3 polyunsaturated fatty acids (n-3 PUFAs) include reduced inflammatory and cardiovascular disease and prevention of cancer.2,3 Apart from the role of n-3 PUFAs in disease prevention, recent studies suggest that n-3 PUFA metabolites may have a place in cancer treatment...''
Δ12-prostaglandin J3, an omega-3 fatty acid–derived metabolite, selectively ablates leukemia stem cells in mice December 22, 2011, Journal Blood
''Δ12-prostaglandin J3, an omega-3 fatty acid–derived metabolite, selectively ablates leukemia stem cells in mice….IP administration of Δ12-PGJ3 to mice infected with Friend erythroleukemia virus or those expressing the chronic myelogenous leukemia oncoprotein BCR-ABL in the hematopoietic stem cell pool completely restored normal hematologic parameters, splenic histology, and enhanced survival. More importantly, Δ12-PGJ3 selectively targeted leukemia stem cells (LSCs) for apoptosis in the spleen and BM. This treatment completely eradicated LSCs in vivo, as demonstrated by the inability of donor cells from treated mice to cause leukemia in secondary transplantations….''
Possible Cure for Leukemia Found in Fish Oil
December 22, 2011, Science Daily
Fish oil may hold key to leukemia cure
December 22, 2011, Eurek Alert
Fish Oil Reduces Effectiveness of Chemotherapy WARNING
September 12, 2011, Science Daily
How much fish oil is too much? IMPORTANT NOTICE
October 6, 2010, Futurity
Fish oil—long encouraged by doctors as a supplement to support heart and joint health—induces severe colitis and colon cancer in mice in new research
