Possible cure for CML in Fish Oil Chronic Myeloid Leukemia
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The compound Δ12-prostaglandin J3, an omega-3 fatty acid–derived metabolite, selectively ablates CML stem cells in mice. This compound is produced from EPA, Eicosapentaenoic Acid, an Omega-3 fatty acid found in fish and in fish oil. The compound Δ12-PGJ3 selectively targeted leukemia stem cells (LSCs) for apoptosis in the spleen and BM.
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Important notice: You must inform your CML doctor or a qualified doctor if you want to take Fish Oil or other product. The material presented here is for information purposes only; it is not a substitute for your physician’s guidance and care. Fish oil—long encouraged by doctors as a supplement to support heart and joint health—induces severe colitis and colon cancer in mice in new research
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''During the experiments, the researchers injected each mouse with about 600 nanograms of D12—PGJ3 each day for a week. Tests showed that the mice were completely cured of the disease. The blood count was normal, and the spleen returned to normal size. The disease did not relapse.''
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''The salutory effects of fish oil ω-3 polyunsaturated fatty acids (n-3 PUFAs) include reduced inflammatory and cardiovascular disease and prevention of cancer.2,3 Apart from the role of n-3 PUFAs in disease prevention, recent studies suggest that n-3 PUFA metabolites may have a place in cancer treatment...''
Δ12-prostaglandin J3, an omega-3 fatty acid–derived metabolite, selectively ablates leukemia stem cells in mice December 22, 2011, Journal Blood
''Δ12-prostaglandin J3, an omega-3 fatty acid–derived metabolite, selectively ablates leukemia stem cells in mice….IP administration of Δ12-PGJ3 to mice infected with Friend erythroleukemia virus or those expressing the chronic myelogenous leukemia oncoprotein BCR-ABL in the hematopoietic stem cell pool completely restored normal hematologic parameters, splenic histology, and enhanced survival. More importantly, Δ12-PGJ3 selectively targeted leukemia stem cells (LSCs) for apoptosis in the spleen and BM. This treatment completely eradicated LSCs in vivo, as demonstrated by the inability of donor cells from treated mice to cause leukemia in secondary transplantations….''
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Fish oil—long encouraged by doctors as a supplement to support heart and joint health—induces severe colitis and colon cancer in mice in new research
Clinical Trials
Omega-3 Fatty Acids in Treating Patients With Advanced Cancer Who Have Significant Weight Loss
Omega-3 Fatty Acids in Treating Patients With Advanced Cancer Who Have Significant Weight Loss
