Side effects - Heart - Chronic Myeloid Leukemia - CML
The potential for QT prolongation associated with nilotinib and dasatinib, although rare, necessitates vigilant monitoring.
ARTICLES
Chronic Myeloid Leukemia: Arterial Occlusive Events in the PACE Trial
October 28, 2022, Cancer Network
A New Paradigm of Cardio-Hematological Monitoring in Chronic Myeloid Leukemia Patients Treated With Tyrosine Kinase Inhibitors
June 8, 2022, Cureus
Treatment of CML With Tyrosine Kinase Inhibitors Associated With Risk of Vascular Adverse Events
December 8, 2021, OncologyNurseAdvisor
Ankle-Brachial Index, Cardiac Ankle Vascular Index May Indicate Risk of Cardiovascular AEs in Patients With CML Taking TKIs
November 23, 2021, Oncology Nurse Advisor
Algorithm Assesses Risk of Major Adverse Cardiovascular Events in TKI-Treated CML
October 21, 2021, Oncology Nurse Advisor
Review of the Cardiovascular Risks of TKI Therapy for Chronic Myeloid Leukemia
September 15, 2021, Oncology Nurse Advisor
Tyrosine kinase inhibitor-associated cardiovascular adverse events in chronic myeloid leukemia
September 9, 2021, Docwirenews
Cardiovascular events and atherogenic lipid profile in chronic myeloid leukemia patients treated with nilotinib versus imatinib
July 20, 2021, docwiresnews
Efficacy and Cardiovascular Adverse Events of Long-term Treatment with Tyrosine Kinase Inhibitors for Chronic Myeloid Leukemia: A Report from the Nagasaki CML Study Group
February 22, 2021, J-Stage
Concomitant Administration of Direct Oral Anticoagulants in Chronic Phase Chronic Myeloid Leukemia Patients Treated with Tyrosine Kinase Inhibitors
October 22, 2020, docwirenews
Collaborative cardiovascular management of patients with chronic myeloid leukemia on tyrosine kinase inhibitors
April 17, 2020 , Sage Journals
Ventricular Arrhythmia Risk Due to Hydroxychloroquine-Azithromycin Treatment For COVID-19
Mar 29, 2020, American College of Cardiology
Long-term mortality rate for cardiovascular disease in 656 chronic myeloid leukaemia patients treated with second- and third-generation tyrosine kinase inhibitor
October 24, 2019, PubMed
Ponatinib in the Treatment of Chronic Myeloid Leukemia and Philadelphia Chromosome-Positive Acute Leukemia: Recommendations of a German Expert Consensus Panel with Focus on Cardiovascular Management
October 7, 2019, Acta Haematologica
Incidence and evaluation of predisposition to cardiovascular toxicity in chronic myeloid leukemia patients treated with bosutinib in the real-life practice
May 1, 2019, PubMed
Analysis of cardiovascular and arteriothrombotic adverse events in chronic-phase CML patients after frontline TKIs
March 26, 2019, PubMed
Cardiac, vascular, and hypertension safety of bosutinib versus imatinib for newly diagnosed chronic myeloid leukemia in the BFORE trial.
2019, American Society of Clinical Oncology
The BCR-ABL1 Inhibitors Imatinib and Ponatinib Decrease Plasma Cholesterol and Atherosclerosis, and Nilotinib and Ponatinib Activate Coagulation in a Translational Mouse Model
June 12, 2018, NCBI
Cardiovascular Health Considerations When Using Tyrosine Kinase Inhibitors
May 4, 2018, JNCCN360
1-year Imatinib or Nilotinib Therapy Not Associated with Cardiotoxity in CML
April 9, 2018, Oncology Nurse Advisor
Peripheral Artery Occlusive Disease Among Patients With Chronic Myeloid Leukemia Receiving Tyrosine Kinase Inhibitors: A Cross-Sectional Case-Control Study
December 15, 2017, PublMed
Cardiovascular toxicities of BCR-ABL tyrosine kinase inhibitors in chronic myeloid leukemia: preventive strategies and cardiovascular surveillance
August 4, 2017, NCBI
The effect of aspirin and anticoagulation on tyrosine kinase inhibitors induced thrombotic events in chronic myeloid leukemia: A retrospective cohort
May 30, 2017, Journal of Clinical Oncology
Cardiovascular Events Among Patients with Chronic Myeloid Leukemia (CML) Treated with Tyrosine Kinase Inhibitors (TKIs)
December 3, 2016, ASH 2016
TKI-induced Cardiovascular Toxicity in Chronic Myeloid Leukemia
November 30, 2016, Cancer Therapy Advisor
BCR-ABL Tyrosine Kinase Inhibitors May Increase Cardiovascular Events in Chronic Myeloid Leukemia
February 16, 2016, Cancer Therapy Advisor
CML arterial adverse events rate dependent on TKI choice
October 22, 2015, News Medical
Incidence and relevance of QTc-interval prolongation caused by tyrosine kinase inhibitors
March 5, 2015, BJC
Life-saving cancer drug can also cause heart damage: Study
February 14, 2014, Ottawa Citizen
Ageing is a risk factor in imatinib mesylate cardiotoxicity
February 6, 2014, PublMed
Nilotinib-Associated Vascular Events.
May 23, 2012, PublMed
Clinical cardiac safety profile of nilotinib.
January 22, 2012, PubLMed
FDA Drug Safety Communication: Sprycel (dasatinib) and risk of pulmonary arterial hypertension
November 10, 2011, U.S. Food and Drug Administration
A prospective evaluation of cardiac function in patients with chronic myeloid leukaemia treated with imatinib
August 2010, Leukemia Research
Reversible Cardiotoxicity with tyrosine kinase inhibitors
February 2010, Clinical advances In Hematology & Oncology
Effect of nilotinib on the pharmacokinetics and pharmacodynamics of warfarin
2009 ASCO annual meeting
Tyrosine kinase inhibitor-induced platelet dysfunction in patients with chronic myeloid leukemia
July 2009, Journal Blood
Leukemia Drug May Improve Stroke Treatment
June 2008, WebMed
Cancer Drug Gleevec Could Fight Stroke
June 2008, HealthDay - eVitamine
Cardiotoxicity of imatinib mesylate: an extremely rare phenomenon or a major side effect?
June 2007, NCBI
Chronic Myeloid Leukemia: Arterial Occlusive Events in the PACE Trial
October 28, 2022, Cancer Network
A New Paradigm of Cardio-Hematological Monitoring in Chronic Myeloid Leukemia Patients Treated With Tyrosine Kinase Inhibitors
June 8, 2022, Cureus
Treatment of CML With Tyrosine Kinase Inhibitors Associated With Risk of Vascular Adverse Events
December 8, 2021, OncologyNurseAdvisor
Ankle-Brachial Index, Cardiac Ankle Vascular Index May Indicate Risk of Cardiovascular AEs in Patients With CML Taking TKIs
November 23, 2021, Oncology Nurse Advisor
Algorithm Assesses Risk of Major Adverse Cardiovascular Events in TKI-Treated CML
October 21, 2021, Oncology Nurse Advisor
Review of the Cardiovascular Risks of TKI Therapy for Chronic Myeloid Leukemia
September 15, 2021, Oncology Nurse Advisor
Tyrosine kinase inhibitor-associated cardiovascular adverse events in chronic myeloid leukemia
September 9, 2021, Docwirenews
Cardiovascular events and atherogenic lipid profile in chronic myeloid leukemia patients treated with nilotinib versus imatinib
July 20, 2021, docwiresnews
Efficacy and Cardiovascular Adverse Events of Long-term Treatment with Tyrosine Kinase Inhibitors for Chronic Myeloid Leukemia: A Report from the Nagasaki CML Study Group
February 22, 2021, J-Stage
Concomitant Administration of Direct Oral Anticoagulants in Chronic Phase Chronic Myeloid Leukemia Patients Treated with Tyrosine Kinase Inhibitors
October 22, 2020, docwirenews
Collaborative cardiovascular management of patients with chronic myeloid leukemia on tyrosine kinase inhibitors
April 17, 2020 , Sage Journals
Ventricular Arrhythmia Risk Due to Hydroxychloroquine-Azithromycin Treatment For COVID-19
Mar 29, 2020, American College of Cardiology
Long-term mortality rate for cardiovascular disease in 656 chronic myeloid leukaemia patients treated with second- and third-generation tyrosine kinase inhibitor
October 24, 2019, PubMed
Ponatinib in the Treatment of Chronic Myeloid Leukemia and Philadelphia Chromosome-Positive Acute Leukemia: Recommendations of a German Expert Consensus Panel with Focus on Cardiovascular Management
October 7, 2019, Acta Haematologica
Incidence and evaluation of predisposition to cardiovascular toxicity in chronic myeloid leukemia patients treated with bosutinib in the real-life practice
May 1, 2019, PubMed
Analysis of cardiovascular and arteriothrombotic adverse events in chronic-phase CML patients after frontline TKIs
March 26, 2019, PubMed
Cardiac, vascular, and hypertension safety of bosutinib versus imatinib for newly diagnosed chronic myeloid leukemia in the BFORE trial.
2019, American Society of Clinical Oncology
The BCR-ABL1 Inhibitors Imatinib and Ponatinib Decrease Plasma Cholesterol and Atherosclerosis, and Nilotinib and Ponatinib Activate Coagulation in a Translational Mouse Model
June 12, 2018, NCBI
Cardiovascular Health Considerations When Using Tyrosine Kinase Inhibitors
May 4, 2018, JNCCN360
1-year Imatinib or Nilotinib Therapy Not Associated with Cardiotoxity in CML
April 9, 2018, Oncology Nurse Advisor
Peripheral Artery Occlusive Disease Among Patients With Chronic Myeloid Leukemia Receiving Tyrosine Kinase Inhibitors: A Cross-Sectional Case-Control Study
December 15, 2017, PublMed
Cardiovascular toxicities of BCR-ABL tyrosine kinase inhibitors in chronic myeloid leukemia: preventive strategies and cardiovascular surveillance
August 4, 2017, NCBI
The effect of aspirin and anticoagulation on tyrosine kinase inhibitors induced thrombotic events in chronic myeloid leukemia: A retrospective cohort
May 30, 2017, Journal of Clinical Oncology
Cardiovascular Events Among Patients with Chronic Myeloid Leukemia (CML) Treated with Tyrosine Kinase Inhibitors (TKIs)
December 3, 2016, ASH 2016
TKI-induced Cardiovascular Toxicity in Chronic Myeloid Leukemia
November 30, 2016, Cancer Therapy Advisor
BCR-ABL Tyrosine Kinase Inhibitors May Increase Cardiovascular Events in Chronic Myeloid Leukemia
February 16, 2016, Cancer Therapy Advisor
CML arterial adverse events rate dependent on TKI choice
October 22, 2015, News Medical
Incidence and relevance of QTc-interval prolongation caused by tyrosine kinase inhibitors
March 5, 2015, BJC
Life-saving cancer drug can also cause heart damage: Study
February 14, 2014, Ottawa Citizen
Ageing is a risk factor in imatinib mesylate cardiotoxicity
February 6, 2014, PublMed
Nilotinib-Associated Vascular Events.
May 23, 2012, PublMed
Clinical cardiac safety profile of nilotinib.
January 22, 2012, PubLMed
FDA Drug Safety Communication: Sprycel (dasatinib) and risk of pulmonary arterial hypertension
November 10, 2011, U.S. Food and Drug Administration
A prospective evaluation of cardiac function in patients with chronic myeloid leukaemia treated with imatinib
August 2010, Leukemia Research
Reversible Cardiotoxicity with tyrosine kinase inhibitors
February 2010, Clinical advances In Hematology & Oncology
Effect of nilotinib on the pharmacokinetics and pharmacodynamics of warfarin
2009 ASCO annual meeting
Tyrosine kinase inhibitor-induced platelet dysfunction in patients with chronic myeloid leukemia
July 2009, Journal Blood
Leukemia Drug May Improve Stroke Treatment
June 2008, WebMed
Cancer Drug Gleevec Could Fight Stroke
June 2008, HealthDay - eVitamine
Cardiotoxicity of imatinib mesylate: an extremely rare phenomenon or a major side effect?
June 2007, NCBI
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