Stem cells  - CML -  Chronic Myeloid Leukemia

"CML has long been considered as a stem cell disease, but detailed characteristics of its stem cells have not been fully elucidated to date. Because CML has the propensity to evolve from a chronic phase to accelerated phase and finally to blast crisis phase, one can pinpoint the phase and developmental stage at which mutations arise. Hence, CML is an important paradigm for understanding both genetic and epigenetic events that drive aberrant stem and progenitor cell differentiation, self-renewal and survival during both early and advanced phases of disease "
Extract of Leukemia stem cells: the root of chronic myeloid leukemia 

VIDEOS

Stem Cells
August 1, 2014, Nucleus Medical Media

A stem cell story
June 14, 2011,  EuroStemCell
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ARTICLES

The leukaemia stem cell: similarities, differences and clinical prospects in CML and AML
January 6, 2020, Nature

Chronic myeloid leukemia stem cells
May 24, 2019, Leukemia

How 'sleeper cell' cancer stem cells are maintained in chronic myelogenous leukemia
March 21, 2019, Medical Xpress

Genetically encoded sensor isolates hidden leukemic stem cells
March 12, 2019, Medical Xpress

​The chronic myeloid leukemia stem cell: stemming the tide of persistence
March 2017, Journal Blood

MS4A3: A New Player in Leukemic Stem Cell Survival in Chronic Myeloid Leukemia
December 5, 2016, ASH2016

Leukemia stem cells: the root of chronic myeloid leukemia
March 10, 2015, NCBI

Cancer as a metabolic disease: implications for novel therapeutics
December 16, 2013, NCBI
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Leukemia - Insights into the stem cells of chronic myeloid leukemia
June 15, 2010, Leukemia

Chronic myeloid leukemia stem cells
2008, PublMed

Characterization of cancer stem cells in chronic myeloid leukaemia.
2007, NCBI

Hematopoietic stem cells in chronic myeloid leukemia
2003, NCBI