Food and Drug Interactions - Chronic Myeloid Leukemia
Several fruits and drugs can cause problems with tyrosine kinase inhibitors (TKI). For example, patients should not drink grapefruit juice or eat grapefruits. Other fruits which should be avoided include star fruits, mulberries and pomegranates.
Please talk to your doctor or to your pharmacist to have the updated information. There are many Drug/Food interaction charts furnished by some CML associations. To begin, visit http://en.wikipedia.org/wiki/CYP3A4 (this site lists drugs that interfere with the body’s ability to metabolize the drugs).
Ask your doctor if you can use pain killer (Advil®, Tylenol®,...) and proton pump inhibitors (Nexium®,...) with tyrosine kinase inhibitors (TKI).
Finally, you have to know that smoking may increase risk of death in patients with CML.
Please talk to your doctor or to your pharmacist to have the updated information. There are many Drug/Food interaction charts furnished by some CML associations. To begin, visit http://en.wikipedia.org/wiki/CYP3A4 (this site lists drugs that interfere with the body’s ability to metabolize the drugs).
Ask your doctor if you can use pain killer (Advil®, Tylenol®,...) and proton pump inhibitors (Nexium®,...) with tyrosine kinase inhibitors (TKI).
Finally, you have to know that smoking may increase risk of death in patients with CML.
"Since imatinib is mainly metabolised via the liver enzyme CYP3A4, substances influencing the activity of this enzyme change the plasma concentration of the drug. An example of a drug that increases imatinib activity and therefore side effects by blocking CYP3A4 is ketoconazole. The same could be true of itraconazole, clarithromycin, grapefruit juice, among others. Conversely, CYP3A4 inductors like rifampicinand St. John's Wort reduce the drug's activity, risking therapy failure. Imatinib also acts as an inhibitor of CYP3A4, 2C9 and 2D6, increasing the plasma concentrations of a number of other drugs like simvastatin,ciclosporin,pimozide, warfarin, metoprolol, and possibly paracetamol. The drug also reduces plasma levels of levothyroxinvia an unknown mechanism.
As with other immunosuppressants, application of live vaccines is contraindicated because the microorganisms in the vaccine could multiply and infect the patient. Inactivated and toxoid vaccines do not hold this risk, but may not be effective under imatinib therapy."
Extract from Wikipedia
VIDEOS
Drug Interactions #1
Drug Interactions #2B
February 23, 2016, RxPrep
CML Horizons 2014: Drug interactions from a pharmacology perspective (Annette Freidank)
May 20, 2014, cmladvocates
Drug Interactions #1
Drug Interactions #2B
February 23, 2016, RxPrep
CML Horizons 2014: Drug interactions from a pharmacology perspective (Annette Freidank)
May 20, 2014, cmladvocates
ARTICLES
The effect of stomach acid suppressants on the safety and effectiveness of dasatinib in patients with chronic myeloid leukemia (CML)
May 23, 2020, Medivizor
Drug interactions with tyrosine kinase inhibitors in chronic myeloid leukemia (CML)
July 17, 2018, Medivisor
Pepsi® or Coke®? Influence of acid on dasatinib absorption
January 1, 2018, PublMed
Two studies find vitamin C can prevent and treat leukemia
August 2017, The San Diego Union-Tribune
Vitamin C may stop leukemia from progressing
August 17, 2017, MedicalNewsToday
High Doses of Vitamin C and Leukaemia: In Vitro Update
June 23, 2017. Scholars.direct
Smoking May Increase Risk of Death in Patients With CML ****WARNING ****
February 14, 2017, Cancer Therapy Advisor
Ponatinib: Black Box Warning and Drug Interactions
January 17, 2017, Cancer Therapy Advisor
About Herbs, Botanicals & Other Products
May 2013, Memorial Sloan Kettering Cancer Center
Lifestyle and Dietary Factors in Relation to Risk of Chronic Myeloid Leukemia in the NIH-AARP Diet and Health Study
April 26, 2013, NCBI
Mechanisms Underlying Food-Drug Interactions: Inhibition of Intestinal Metabolism and Transport
August 4, 2012, NCBI
Contrasting effects of diclofenac and ibuprofen also known as (Advil®, Brufen®, Motrin®, Nuprin®, Nurofen®) on active imatinib uptake into leukaemic cells ****WARNING ****
April 24, 2012, Nature
Drug & food interactions
July 2011, The National CML Society
Drug interactions with the tyrosine kinase inhibitors imatinib, dasatinib, and nilotinib
See the table on a pdf file *** IMPORTANT ***
February 24, 2011,Journal Blood
Drug/Food Interaction Chart
August 2010, CML Society of Canada
Effect of a proton pump inhibitor on the pharmacokinetics of imatinib
September 2009, PublMed
Vitamin C May Interfere With Cancer Treatment
October 1, 2008, The New York Times
Vitamin C antagonizes the cytotoxic effects of antineoplastic drugs
July 25, 2008, Cancer Research ****WARNING ****
The Effect of the Interaction between Proton Pump Inhibitors (PPI) and Tyrosine Kinase Inhibitors (Imatinib, Nilotinib and Dasatinib). ****WARNING ****
2007, Journal Blood
Potential drug interactions with imatinib therapy identified
February 1, 2006, Healio
The effect of stomach acid suppressants on the safety and effectiveness of dasatinib in patients with chronic myeloid leukemia (CML)
May 23, 2020, Medivizor
Drug interactions with tyrosine kinase inhibitors in chronic myeloid leukemia (CML)
July 17, 2018, Medivisor
Pepsi® or Coke®? Influence of acid on dasatinib absorption
January 1, 2018, PublMed
Two studies find vitamin C can prevent and treat leukemia
August 2017, The San Diego Union-Tribune
Vitamin C may stop leukemia from progressing
August 17, 2017, MedicalNewsToday
High Doses of Vitamin C and Leukaemia: In Vitro Update
June 23, 2017. Scholars.direct
Smoking May Increase Risk of Death in Patients With CML ****WARNING ****
February 14, 2017, Cancer Therapy Advisor
Ponatinib: Black Box Warning and Drug Interactions
January 17, 2017, Cancer Therapy Advisor
About Herbs, Botanicals & Other Products
May 2013, Memorial Sloan Kettering Cancer Center
Lifestyle and Dietary Factors in Relation to Risk of Chronic Myeloid Leukemia in the NIH-AARP Diet and Health Study
April 26, 2013, NCBI
Mechanisms Underlying Food-Drug Interactions: Inhibition of Intestinal Metabolism and Transport
August 4, 2012, NCBI
Contrasting effects of diclofenac and ibuprofen also known as (Advil®, Brufen®, Motrin®, Nuprin®, Nurofen®) on active imatinib uptake into leukaemic cells ****WARNING ****
April 24, 2012, Nature
Drug & food interactions
July 2011, The National CML Society
Drug interactions with the tyrosine kinase inhibitors imatinib, dasatinib, and nilotinib
See the table on a pdf file *** IMPORTANT ***
February 24, 2011,Journal Blood
Drug/Food Interaction Chart
August 2010, CML Society of Canada
Effect of a proton pump inhibitor on the pharmacokinetics of imatinib
September 2009, PublMed
Vitamin C May Interfere With Cancer Treatment
October 1, 2008, The New York Times
Vitamin C antagonizes the cytotoxic effects of antineoplastic drugs
July 25, 2008, Cancer Research ****WARNING ****
The Effect of the Interaction between Proton Pump Inhibitors (PPI) and Tyrosine Kinase Inhibitors (Imatinib, Nilotinib and Dasatinib). ****WARNING ****
2007, Journal Blood
Potential drug interactions with imatinib therapy identified
February 1, 2006, Healio