Sprycel (dasatinib) - CML - Chronic Myeloid Leukemia
''Dasatinib, also known as BMS-354825, is a cancer drug produced by Bristol-Myers Squibband sold under the trade name Sprycel. Dasatinib is an oral dual BCR/ABL and Src family tyrosine kinases inhibitorapproved for use in patients with chronic myelogenous leukemia (CML) after imatinib treatment and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). It is also being assessed for use in metastaticmelanoma.
The drug is named after one of the inventor chemists, Jagabandhu Das, who was a member of the large discovery and development team at Bristol Myers Squibb.''
Extract of Wikipedia
The drug is named after one of the inventor chemists, Jagabandhu Das, who was a member of the large discovery and development team at Bristol Myers Squibb.''
Extract of Wikipedia
SITES
Direct effect of dasatinib
on proliferation and cytotoxicity of natural killer cells in in vitro study.
October 29, 2012, PublMed
A trial of dasatinib and BMS-833923 for chronic myeloid leukaemia (CA180323)
October 22, 2012, Cancer Research UK
Rapid Amelioration of Hyperglycemia Facilitated by Dasatinib in a Chronic Myeloid Leukemia Patient with type 2 Diabetes Mellitus
October 1, 2012, PublMed
Enhancement of natural killer cell effector functions against selected lymphoma and leukemia cell lines by dasatinib.
September 15, 2012, PublMed
Dasatinib Achieves Higher Response Rate Than Imatinib in CML
September 6, 2012, Cancer Network
Sprycel Picks Up the Pieces
June 28, 2012, DailyRX
Predictive value of early molecular response in patients with chronic myeloid leukemia treated with first line dasatinib
May 29, 2012, Journal Blood
Design, synthesis, and in vitro antiproliferative activity of novel Dasatinib derivatives
January 15, 2012, PubLMed
Src inhibitors, PP2 and dasatinib, increase retinoic acid-induced association of Lyn and c-Raf (S259) and enhance MAPK-dependent differentiation of myeloid leukemia cells
December 19, 2011, Nature
FDA Drug Safety Communication: Sprycel (dasatinib) and risk of pulmonary arterial hypertension
November 10, 2011, U.S. Food and Drug Administration
Leukemia drug Sprycel linked to dangerous side effect
August 30, 2011, The Canadian Press
Risk of pulmonary arterial hypertension with Sprycel (dasatinib)
August 16, 2011, CBG-MEB
Dasatinib Shows Superior Efficacy and Acceptable Tolerability, Supporting First-Line Use in Newly Diagnosed CML-CP
June 3 , 2011, Monthly Prescribing Reference
FDA Approves SPRYCEL® (dasatinib) as Treatment for Adult Patients with Newly Diagnosed Ph+ Chronic Myeloid Leukemia
October 28, 2010, FierceBiotech
Dasatinib, an immunomodulator?
August 2010, Journal Blood
Tyrosine kinase inhibitor-induced platelet dysfunction in patients with chronic myeloid leukemia - Dasatinib is associated with increased risk of bleeding
July 9, 2009, Journal Blood
Targeted therapies for CML: practical considerations and comparisons
August 10, 2008, HemOncToday
Dasatinib suppresses in vitro natural killer cell cytotoxicity
April 15, 2008, Journal Blood
Profound inhibition of antigen-specific T-cell effector functions by dasatinib.
April 8, 2008, PublMed
October 29, 2012, PublMed
A trial of dasatinib and BMS-833923 for chronic myeloid leukaemia (CA180323)
October 22, 2012, Cancer Research UK
Rapid Amelioration of Hyperglycemia Facilitated by Dasatinib in a Chronic Myeloid Leukemia Patient with type 2 Diabetes Mellitus
October 1, 2012, PublMed
Enhancement of natural killer cell effector functions against selected lymphoma and leukemia cell lines by dasatinib.
September 15, 2012, PublMed
Dasatinib Achieves Higher Response Rate Than Imatinib in CML
September 6, 2012, Cancer Network
Sprycel Picks Up the Pieces
June 28, 2012, DailyRX
Predictive value of early molecular response in patients with chronic myeloid leukemia treated with first line dasatinib
May 29, 2012, Journal Blood
Design, synthesis, and in vitro antiproliferative activity of novel Dasatinib derivatives
January 15, 2012, PubLMed
Src inhibitors, PP2 and dasatinib, increase retinoic acid-induced association of Lyn and c-Raf (S259) and enhance MAPK-dependent differentiation of myeloid leukemia cells
December 19, 2011, Nature
FDA Drug Safety Communication: Sprycel (dasatinib) and risk of pulmonary arterial hypertension
November 10, 2011, U.S. Food and Drug Administration
Leukemia drug Sprycel linked to dangerous side effect
August 30, 2011, The Canadian Press
Risk of pulmonary arterial hypertension with Sprycel (dasatinib)
August 16, 2011, CBG-MEB
Dasatinib Shows Superior Efficacy and Acceptable Tolerability, Supporting First-Line Use in Newly Diagnosed CML-CP
June 3 , 2011, Monthly Prescribing Reference
FDA Approves SPRYCEL® (dasatinib) as Treatment for Adult Patients with Newly Diagnosed Ph+ Chronic Myeloid Leukemia
October 28, 2010, FierceBiotech
Dasatinib, an immunomodulator?
August 2010, Journal Blood
Tyrosine kinase inhibitor-induced platelet dysfunction in patients with chronic myeloid leukemia - Dasatinib is associated with increased risk of bleeding
July 9, 2009, Journal Blood
Targeted therapies for CML: practical considerations and comparisons
August 10, 2008, HemOncToday
Dasatinib suppresses in vitro natural killer cell cytotoxicity
April 15, 2008, Journal Blood
Profound inhibition of antigen-specific T-cell effector functions by dasatinib.
April 8, 2008, PublMed
Dr. Sonali Smith talks about some of the advances in chronic myeloid leukemia care coming out of the 2010 ASCO Annual Meeting |
New leukemia treatment - Sprycel
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