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Chronic Myeloid Leukemia

Sprycel (dasatinib)  -  CML  -   Chronic Myeloid Leukemia

''Dasatinib, also known as BMS-354825, is a cancer drug produced by Bristol-Myers Squibband sold under the trade name Sprycel. Dasatinib is an oral dual BCR/ABL and Src family tyrosine kinases inhibitorapproved for use in patients with chronic myelogenous leukemia (CML) after imatinib treatment and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). It is also being assessed for use in metastaticmelanoma.
The drug is named after one of the inventor chemists,
Jagabandhu Das, who was a member of the large discovery and development team at Bristol Myers Squibb.''
Extract of  
Wikipedia

SITES

Picture
Sprycel


FORUMS    

Sprycel Talk - by the support group Newcmldrug.com
Sprycel on Facebook      



Direct effect of dasatinib on proliferation and cytotoxicity of natural killer cells in in vitro study.
October 29, 2012,  
PublMed

A trial of dasatinib and BMS-833923 for chronic myeloid  leukaemia (CA180323)
October 22, 2012,  Cancer Research  UK

Rapid Amelioration of Hyperglycemia Facilitated by Dasatinib in a Chronic Myeloid Leukemia Patient with type 2 Diabetes Mellitus

October 1, 2012, PublMed

Enhancement of natural killer cell effector functions against selected lymphoma and leukemia cell lines by  dasatinib.
September 15, 2012,  PublMed

Dasatinib Achieves Higher Response Rate Than Imatinib in CML
September 6, 2012, Cancer Network

Sprycel Picks Up the Pieces
June 28, 2012, DailyRX

Predictive value of early molecular response in patients with chronic myeloid leukemia treated with first line dasatinib   
May 29, 2012, Journal Blood

Design, synthesis, and in vitro antiproliferative activity of novel Dasatinib derivatives
January 15, 2012, PubLMed

Src inhibitors, PP2 and dasatinib, increase retinoic acid-induced association of Lyn and c-Raf (S259) and enhance MAPK-dependent differentiation of myeloid leukemia cells
December 19, 2011,
Nature

FDA Drug Safety Communication: Sprycel (dasatinib) and risk of pulmonary arterial hypertension
November 10, 2011, U.S. Food and Drug Administration

Leukemia drug Sprycel linked to dangerous side effect
August 30, 2011, The Canadian Press

Risk of pulmonary arterial hypertension with Sprycel (dasatinib)

August 16, 2011, CBG-MEB

Dasatinib Shows Superior Efficacy and Acceptable Tolerability, Supporting First-Line Use in Newly Diagnosed CML-CP
June 3 , 2011,  Monthly Prescribing Reference

FDA Approves SPRYCEL® (dasatinib) as Treatment for Adult Patients with Newly Diagnosed Ph+ Chronic Myeloid Leukemia
October 28, 2010,
FierceBiotech

Dasatinib, an immunomodulator?
August 2010, Journal Blood

Tyrosine kinase inhibitor-induced platelet dysfunction in patients with chronic myeloid leukemia - Dasatinib is associated with increased risk of bleeding
July 9, 2009, Journal Blood

Targeted therapies for CML: practical considerations and comparisons
August 10, 2008,
HemOncToday

Dasatinib suppresses in vitro natural killer cell cytotoxicity
April 15, 2008, Journal Blood

Profound inhibition of antigen-specific T-cell effector functions by dasatinib.
April 8, 2008, PublMed




Dr. Sonali Smith talks about some of the advances in chronic myeloid leukemia care coming out of the 2010 ASCO Annual Meeting




 New  leukemia treatment - Sprycel 
     
by Info4YourLife ---- 2007
            










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