Chronic Myeloid Leukemia

‘’Several fruits can also cause problems and patients should not drink grapefruit juice or eat grapefruits. Other fruits available in Australia which should be avoided include star fruit, mulberries and pomegranates. For more detailed information please talk to your doctor or visit http://en.wikipedia.org/wiki/CYP3A4 (this site lists drugs that interfere with the body’s ability to metabolise the drugs).

WHY GRAPEFRUIT INTERFERES WITH GLIVEC
Chronic myeloid leukaemia patients being treated with a tyrosine kinase inhibitor (TKI), such as Glivec®, are warned not to eat grapefruits or drink grapefruit juice. Grapefruit is one of several fruits and herbs which can stop TKIs from working. Grapefruit juice induces the lining of the stomach to produce cytochrome, which in turn metabolises the drug before it can reach the blood system.’’

February 2009,  Extract of http://www.leukaemia.org.au/fileadmin/dl-docs/booklets/Carer_Feb09.pdf
                     

          
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