Food and Drug Interactions - Chronic Myeloid Leukemia
Contrasting effects of diclofenac and ibuprofen also known as (Advil, Brufen, Motrin, Nuprin, Nurofen) on active imatinib uptake into leukaemic cells
More about diclofenac and ibuprofen
April 24, 2012, Nature
Drug & food interactions
July 2011, The National CML Society
Gleevec Interactions
November 2010, Gist Support International
Drug interactions with the tyrosine kinase inhibitors imatinib, dasatinib, and nilotinib
See the table on a pdf file
August 2010, Journal Blood
More about diclofenac and ibuprofen
April 24, 2012, Nature
Drug & food interactions
July 2011, The National CML Society
Gleevec Interactions
November 2010, Gist Support International
Drug interactions with the tyrosine kinase inhibitors imatinib, dasatinib, and nilotinib
See the table on a pdf file
August 2010, Journal Blood
Gleevec (Imatinib) Drug Interactions by Drugs.com
Tasigna (Nilotinib) Drug Interactions
Sprycel (Dasatinib) Drug Interactions
Tasigna (Nilotinib) Drug Interactions
Sprycel (Dasatinib) Drug Interactions
‘’Several fruits can also cause problems and patients should not drink grapefruit juice or eat grapefruits. Other fruits available in Australia which should be avoided include star fruit, mulberries and pomegranates. For more detailed information please talk to your doctor or visit http://en.wikipedia.org/wiki/CYP3A4 (this site lists drugs that interfere with the body’s ability to metabolise the drugs).
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WHY GRAPEFRUIT INTERFERES WITH GLIVEC
Chronic myeloid leukaemia patients being treated with a tyrosine kinase inhibitor (TKI), such as Glivec®, are warned not to eat grapefruits or drink grapefruit juice. Grapefruit is one of several fruits and herbs which can stop TKIs from working. Grapefruit juice induces the lining of the stomach to produce cytochrome, which in turn metabolises the drug before it can reach the blood system.’’
February 2009, Extract of http://www.leukaemia.org.au/fileadmin/dl-docs/booklets/Carer_Feb09.pdf
Chronic myeloid leukaemia patients being treated with a tyrosine kinase inhibitor (TKI), such as Glivec®, are warned not to eat grapefruits or drink grapefruit juice. Grapefruit is one of several fruits and herbs which can stop TKIs from working. Grapefruit juice induces the lining of the stomach to produce cytochrome, which in turn metabolises the drug before it can reach the blood system.’’
February 2009, Extract of http://www.leukaemia.org.au/fileadmin/dl-docs/booklets/Carer_Feb09.pdf
"Since imatinib is mainly metabolised via the liver enzyme CYP3A4, substances influencing the activity of this enzyme change the plasma concentration of the drug. An example of a drug that increases imatinib activity
and therefore side effects by blocking CYP3A4 is ketoconazole. The same could be true of itraconazole, clarithromycin, grapefruit juice, among others. Conversely, CYP3A4 inductors like rifampicinand St. John's
Wort reduce the drug's activity, risking therapy failure. Imatinib also acts as an inhibitor of CYP3A4, 2C9 and 2D6, increasing the plasma concentrations of a number of other drugs like simvastatin,ciclosporin,pimozide, warfarin, metoprolol, and possibly paracetamol. The drug also reduces plasma levels of levothyroxinvia an unknown mechanism.
As with other immunosuppressants, application of live vaccines is contraindicated because the microorganisms in the vaccine could multiply and infect the patient. Inactivated and toxoid vaccines do not hold this risk, but may not be effective under imatinib therapy."
Extract from Wikipedia
and therefore side effects by blocking CYP3A4 is ketoconazole. The same could be true of itraconazole, clarithromycin, grapefruit juice, among others. Conversely, CYP3A4 inductors like rifampicinand St. John's
Wort reduce the drug's activity, risking therapy failure. Imatinib also acts as an inhibitor of CYP3A4, 2C9 and 2D6, increasing the plasma concentrations of a number of other drugs like simvastatin,ciclosporin,pimozide, warfarin, metoprolol, and possibly paracetamol. The drug also reduces plasma levels of levothyroxinvia an unknown mechanism.
As with other immunosuppressants, application of live vaccines is contraindicated because the microorganisms in the vaccine could multiply and infect the patient. Inactivated and toxoid vaccines do not hold this risk, but may not be effective under imatinib therapy."
Extract from Wikipedia
Vitamin C and Cancer
Vitamin C supplements may undercut the effectiveness of cancer drugs including Novartis' Gleevec, a U.S. study published on Wednesday showed.
When used on human cancer cells treated with a form of vitamin C in lab dishes, chemotherapy drugs killed 30 percent to 70 percent fewer tumor cells than usual, the scientists wrote in the journal Cancer Research.
October 2008, Natural Health News
Vitamin C may blunt effect of chemotherapy: study
October 1, 2008, Reuters
Vitamin C May Interfere With Cancer Treatment
October 1, 2008, The New York Times
Vitamin C may blunt effect of chemotherapy: study
October 2008, Asiaone Health
HOME :: Cancer Straight Talk on Vitamin C During Chemotherapy Treatment
November 2008, Ezines Aricles
VITAMIN C - Good or Bad combined with Chemotherapy?
October 2008, Squidoo
Vitamin C antagonizes the cytotoxic effects of antineoplastic drugs
July 25,, 2008, Cancer Research
Can Vitamin C Really Treat Cancer?
January 2009, Articlesbase
